{"id":1508,"date":"2020-08-14T10:42:56","date_gmt":"2020-08-14T03:42:56","guid":{"rendered":"http:\/\/sci.edu.vn\/?p=1508"},"modified":"2024-11-24T23:07:51","modified_gmt":"2024-11-24T16:07:51","slug":"cong-nghe-cryosave-giai-phap-bao-quan-dong-lanh-hoan-hao-cho-te-bao-goc","status":"publish","type":"post","link":"https:\/\/sci.edu.vn\/home\/blog\/2020\/08\/14\/cong-nghe-cryosave-giai-phap-bao-quan-dong-lanh-hoan-hao-cho-te-bao-goc\/","title":{"rendered":"C\u00d4NG NGH\u1ec6 CRYOSAVE – Gi\u1ea3i ph\u00e1p b\u1ea3o qu\u1ea3n \u0111\u00f4ng l\u1ea1nh ho\u00e0n h\u1ea3o cho t\u1ebf b\u00e0o g\u1ed1c"},"content":{"rendered":"\n
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C\u00d4NG NGH\u1ec6 CRYOSAVE<\/h2>\n\n\n\n

Gi\u1ea3i ph\u00e1p b\u1ea3o qu\u1ea3n \u0111\u00f4ng l\u1ea1nh ho\u00e0n h\u1ea3o cho t\u1ebf b\u00e0o g\u1ed1c<\/h2>\n\n\n\n
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CryoSave l\u00e0 d\u00f2ng s\u1ea3n ph\u1ea9m m\u00f4i tr\u01b0\u1eddng s\u1eed d\u1ee5ng cho b\u1ea3o qu\u1ea3n t\u1ebf b\u00e0o g\u1ed1c
CryoSave \u0111\u01b0\u1ee3c b\u1eaft \u0111\u1ea7u nghi\u00ean c\u1ee9u t\u1eeb n\u0103m 2008 b\u1edfi Ti\u1ebfn s\u0129 Ph\u1ea1m V\u0103n Ph\u00fac, t\u1ea1i Vi\u1ec7n T\u1ebf b\u00e0o g\u1ed1c, Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Khoa h\u1ecdc T\u1ef1 nhi\u00ean, \u0110\u1ea1i h\u1ecdc Qu\u1ed1c gia Tp.HCM. V\u1edbi m\u1ee5c \u0111\u00edch t\u1ea1o ra m\u1ed9t m\u00f4i tr\u01b0\u1eddng b\u1ea3o qu\u1ea3n \u0111\u00f4ng l\u1ea1nh ho\u00e0n h\u1ea3o cho t\u1ebf b\u00e0o g\u1ed1c, \u0111\u1ebfn n\u0103m 2016, th\u1ebf h\u1ec7 CryoSave \u0111\u1ea7u ti\u00ean (CryoSave I) \u0111\u01b0\u1ee3c ho\u00e0n thi\u1ec7n v\u00e0 \u0111\u01b0a ra th\u1ecb tr\u01b0\u1eddng.
N\u0103m 2017, th\u1ebf h\u1ec7 th\u1ee9 2 c\u1ee7a m\u00f4i tr\u01b0\u1eddng CryoSave \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u th\u00e0nh c\u00f4ng (CryoSave II). V\u00e0 \u0111\u1ebfn n\u0103m 2019, th\u1ebf h\u1ec7 th\u1ee9 3 c\u1ee7a CryoSave (CryoSave III) \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u th\u00e0nh c\u00f4ng.
CryoSave I, II v\u00e0 III l\u00e0 3 th\u1ebf h\u1ec7 c\u1ee7a m\u00f4i tr\u01b0\u1eddng b\u1ea3o qu\u1ea3n \u0111\u00f4ng l\u1ea1nh t\u1ebf b\u00e0o g\u1ed1c v\u1edbi c\u00e1c c\u00f4ng ngh\u1ec7 kh\u00e1c nhau, v\u00e0 m\u1ee5c \u0111\u00edch s\u1eed d\u1ee5ng c\u0169ng kh\u00e1c nhau.<\/p>\n\n\n\n

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Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ec9 hi\u1ec3u t\u1ebf b\u00e0o g\u1ed1c m\u00e0 c\u00f2n hi\u1ec3u b\u1ea1n<\/p>\n<\/blockquote>\n\n\n\n

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B\u1ea3o qu\u1ea3n \u0111\u00f4ng l\u1ea1nh (Cryopreservation) l\u00e0 m\u1ed9t qu\u00e1 tr\u00ecnh b\u1ea3o qu\u1ea3n t\u1ebf b\u00e0o, m\u00f4\u2026 \u1edf nhi\u1ec7t \u0111\u1ed9 th\u1ea5p. \u1ede nhi\u1ec7t \u0111\u1ed9 \u0111\u1ee7 th\u1ea5p, ho\u1ea1t t\u00ednh c\u1ee7a c\u00e1c enzyme b\u1ecb ng\u01b0ng l\u1ea1i ho\u00e0n to\u00e0n.<\/p>\n\n\n\n

Vi\u1ec7c \u0111\u00f4ng l\u1ea1nh th\u01b0\u1eddng g\u00e2y ch\u1ebft t\u1ebf b\u00e0o b\u1edfi v\u00ec s\u1ef1 h\u00ecnh th\u00e0nh c\u00e1c tinh th\u1ec3 n\u01b0\u1edbc \u0111\u00e1 b\u00ean trong t\u1ebf b\u00e0o ch\u1ea5t m\u00e0 g\u00e2y v\u1ee1 c\u1ea5u tr\u00fac protein, b\u00e0o quan c\u1ee7a t\u1ebf b\u00e0o. V\u00ec th\u1ebf, vi\u1ec7c s\u1eed d\u1ee5ng ch\u1ea5t b\u1ea3o qu\u1ea3n l\u1ea1nh (cryoprotectant) \u0111\u00e3 gi\u1ea3m \u0111\u00e1ng k\u1ec3 nh\u1eefng t\u00e1c \u0111\u1ed9ng b\u1ea5t l\u1ee3i n\u00e0y. M\u1ed9t s\u1ed1 ch\u1ea5t b\u1ea3o qu\u1ea3n l\u1ea1nh \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong b\u1ea3o qu\u1ea3n \u0111\u00f4ng l\u1ea1nh t\u1ebf b\u00e0o nh\u01b0 DMSO, glycerol, polypropylene, trehalose\u2026 Trong \u0111\u00f3 DMSO l\u00e0 ch\u1ea5t s\u1eed d\u1ee5ng nhi\u1ec1u nh\u1ea5t trong b\u1ea3o qu\u1ea3n t\u1ebf b\u00e0o g\u1ed1c; \u0111\u1eb7c bi\u1ec7t l\u00e0 t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4. <\/p>\n\n\n\n

Tuy nhi\u00ean, DMSO l\u00e0 ch\u1ea5t \u0111\u1ed9c v\u1edbi t\u1ebf b\u00e0o n\u00ean c\u00f3 nhi\u1ec1u t\u00e1c \u0111\u1ed9ng b\u1ea5t l\u1ee3i l\u00ean t\u1ebf b\u00e0o. Nhi\u1ec1u c\u00f4ng ngh\u1ec7 m\u1edbi ph\u00e1t tri\u1ec3n trong th\u1eddi gian g\u1ea7n \u0111\u00e2y nh\u1eb1m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 DMSO hay lo\u1ea1i b\u1ecf ho\u00e0n to\u00e0n ch\u1ea5t b\u1ea3o qu\u1ea3n l\u1ea1nh trong m\u00f4i tr\u01b0\u1eddng b\u1ea3o qu\u1ea3n \u0111\u00f4ng l\u1ea1nh t\u1ebf b\u00e0o g\u1ed1c. <\/p>\n\n\n\n

Trong th\u1eddi gian g\u1ea7n \u0111\u00e2y, c\u00f4ng ngh\u1ec7 offthe-shelf stem cell m\u1edf ra m\u1ed9t k\u1ec9 nguy\u00ean m\u1edbi cho t\u1ebf b\u00e0o g\u1ed1c; v\u00e0 nhu c\u1ea7u s\u1eed d\u1ee5ng m\u00f4i tr\u01b0\u1eddng b\u1ea3o qu\u1ea3n \u0111\u00f4ng l\u1ea1nh kh\u00f4ng \u0111\u1ed9c, c\u00f3 th\u1ec3 ti\u00eam truy\u1ec1n v\u00e0o c\u01a1 th\u1ec3 c\u00f9ng v\u1edbi t\u1ebf b\u00e0o g\u1ed1c ng\u00e0y c\u00e0ng t\u0103ng.<\/p>\n<\/div><\/div>\n\n\n\n

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V\u1edbi m\u1ee5c \u0111\u00edch t\u1ea1o ra m\u1ed9t m\u00f4i tr\u01b0\u1eddng b\u1ea3o qu\u1ea3n \u0111\u00f4ng l\u1ea1nh t\u1ebf b\u00e0o g\u1ed1c hi\u1ec7u qu\u1ea3 t\u1ebf b\u00e0o s\u1ed1ng cao sau r\u00e3 \u0111\u00f4ng, an to\u00e0n khi s\u1eed d\u1ee5ng, ti\u1ec7n d\u1ee5ng; \u0111\u1eb7c bi\u1ec7t c\u00f4ng ngh\u1ec7 t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 off-the-shelf; CryoSave l\u00e0 d\u00f2ng s\u1ea3n ph\u1ea9m \u0111\u00e1p \u1ee9ng m\u1ecdi nhu c\u1ea7u s\u1eed d\u1ee5ng c\u1ee7a b\u1ea1n t\u1eeb nghi\u00ean c\u1ee9u c\u01a1 b\u1ea3n, nghi\u00ean c\u1ee9u \u1ee9ng d\u1ee5ng v\u00e0 s\u1ea3n xu\u1ea5t s\u1ea3n ph\u1ea9m t\u1ebf b\u00e0o g\u1ed1c off-theshelf.<\/p>\n<\/div>\n\n\n\n

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H\u1ea7u h\u1ebft c\u00e1c m\u00f4i tr\u01b0\u1eddng b\u1ea3o qu\u1ea3n \u0111\u00f4ng l\u1ea1nh hi\u1ec7n c\u00f3 tr\u00ean th\u1ecb tr\u01b0\u1eddng ph\u1ea3i b\u1ea3o qu\u1ea3n \u1edf -20 oC hay 2-8 oC v\u00ec ch\u1ee9a c\u00e1c ch\u1ea5t kh\u00f4ng \u1ed5n \u0111\u1ecbnh \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng. Do \u0111\u00f3 vi\u1ec7c v\u1eadn chuy\u1ec3n c\u00e1c s\u1ea3n ph\u1ea9m n\u00e0y ph\u1ee9c t\u1ea1p v\u00e0 chi ph\u00ed cao.<\/p>\n<\/div>\n<\/div>\n\n\n\n

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CyroSave – m\u00f4i tr\u01b0\u1eddng b\u1ea3o qu\u1ea3n \u0111\u00f4ng l\u1ea1nh duy nh\u1ea5t c\u00f3 th\u1ec3 l\u01b0u tr\u1eef v\u00e0 v\u1eadn chuy\u1ec3n \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng<\/p>\n<\/blockquote>\n\n\n\n

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CryoSave I<\/h3>\n\n\n\n

Th\u00edch h\u1ee3p b\u1ea3o qu\u1ea3n t\u1ebf b\u00e0o g\u1ed1c ph\u1ee5c v\u1ee5 cho nghi\u00ean c\u1ee9u, nghi\u00ean c\u1ee9u chuy\u1ec3n giao. T\u1ebf b\u00e0o g\u1ed1c c\u1ea7n r\u1eeda, lo\u1ea1i b\u1ecf dung d\u1ecbch b\u1ea3o qu\u1ea3n tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng<\/p>\n<\/div>\n\n\n\n

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CryoSave II<\/h3>\n\n\n\n

Th\u00edch h\u1ee3p b\u1ea3o qu\u1ea3n t\u1ebf b\u00e0o g\u1ed1c ph\u1ee5c v\u1ee5 cho nghi\u00ean c\u1ee9u, nghi\u00ean c\u1ee9u chuy\u1ec3n giao, nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng, s\u1eed d\u1ee5ng l\u00e2m s\u00e0ng; kh\u00f4ng c\u1ea7n lo\u1ea1i b\u1ecf m\u00f4i tr\u01b0\u1eddng b\u1ea3o qu\u1ea3n<\/p>\n<\/div>\n\n\n\n

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CryoSave III<\/h3>\n\n\n\n

Th\u00edch h\u1ee3p s\u1ea3n xu\u1ea5t t\u1ebf b\u00e0o g\u1ed1c off-the-shelf, thu\u1ed1c t\u1ebf b\u00e0o g\u1ed1c; kh\u00f4ng c\u1ea7n lo\u1ea1i b\u1ecf m\u00f4i tr\u01b0\u1eddng b\u1ea3o qu\u1ea3n tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng<\/p>\n<\/div>\n<\/div>\n\n\n\n

\"\"<\/figure>\n\n\n\n

So s\u00e1nh v\u1edbi c\u00e1c s\u1ea3n ph\u1ea9m c\u1ea1nh tranh<\/h2>\n\n\n\n
\"\"<\/figure>\n\n\n\n
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CryoSave III – gi\u1ea3i ph\u00e1p ho\u00e0n h\u1ea3o
cho thu\u1ed1c t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4<\/strong><\/h1>\n<\/div>\n<\/div>\n\n\n\n
\"\"<\/figure>\n\n\n\n
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>>> T\u1ea3i brochure CRYOSAVE t\u1ea1i \u0111\u00e2y <<<<\/strong><\/a><\/div>\n<\/div>\n\n\n\n

<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

CryoSave l\u00e0 d\u00f2ng s\u1ea3n ph\u1ea9m m\u00f4i tr\u01b0\u1eddng s\u1eed d\u1ee5ng cho b\u1ea3o qu\u1ea3n t\u1ebf b\u00e0o g\u1ed1c
\nCryoSave \u0111\u01b0\u1ee3c b\u1eaft \u0111\u1ea7u nghi\u00ean c\u1ee9u t\u1eeb n\u0103m 2008 b\u1edfi Ti\u1ebfn s\u0129 Ph\u1ea1m V\u0103n Ph\u00fac, t\u1ea1i Vi\u1ec7n T\u1ebf b\u00e0o g\u1ed1c, Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Khoa h\u1ecdc T\u1ef1 nhi\u00ean, \u0110\u1ea1i h\u1ecdc Qu\u1ed1c gia Tp.HCM. <\/p>\n","protected":false},"author":291,"featured_media":1255,"comment_status":"open","ping_status":"open","sticky":false,"template":"full-width","format":"standard","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[160],"tags":[],"class_list":["post-1508","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cong-nghe"],"jetpack_featured_media_url":"https:\/\/sci.edu.vn\/home\/wp-content\/uploads\/2020\/03\/Depositphotos_69253491_l-2015-e1597376526108.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts\/1508","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/users\/291"}],"replies":[{"embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/comments?post=1508"}],"version-history":[{"count":5,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts\/1508\/revisions"}],"predecessor-version":[{"id":4707,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts\/1508\/revisions\/4707"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/media\/1255"}],"wp:attachment":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/media?parent=1508"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/categories?post=1508"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/tags?post=1508"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}