{"id":3653,"date":"2020-03-18T10:17:52","date_gmt":"2020-03-18T03:17:52","guid":{"rendered":"http:\/\/new.vientebaogoc.edu.vn\/?post_type=blog_post&p=1079"},"modified":"2024-11-24T07:58:42","modified_gmt":"2024-11-24T00:58:42","slug":"co-che-hoat-dong-cua-te-bao-goc-trung-mo-trong-dieu-tri-benh","status":"publish","type":"post","link":"https:\/\/sci.edu.vn\/home\/blog\/2020\/03\/18\/co-che-hoat-dong-cua-te-bao-goc-trung-mo-trong-dieu-tri-benh\/","title":{"rendered":"C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh"},"content":{"rendered":"\n

Khi \u0111\u1ebfn \u0111\u01b0\u1ee3c v\u1ecb tr\u00ed t\u1ed5n th\u01b0\u01a1ng th\u00ec t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 s\u1ebd th\u1ef1c hi\u1ec7n ch\u1ee9c n\u0103ng s\u1eeda ch\u1eefa b\u1eb1ng c\u00e1c c\u00e1ch kh\u00e1c nhau nh\u01b0 ti\u1ebfp t\u1ee5c t\u0103ng sinh \u0111\u1ec3 cung c\u1ea5p ngu\u1ed3n t\u1ebf b\u00e0o g\u1ed1c cho s\u1eeda ch\u1eefa t\u1ed5n th\u01b0\u01a1ng, tham gia bi\u1ec7t h\u00f3a tr\u1ef1c ti\u1ebfp th\u00e0nh t\u1ebf b\u00e0o ch\u1ee9c n\u0103ng, ho\u1eb7c ti\u1ebft ra c\u00e1c y\u1ebfu t\u1ed1 gi\u00fap huy \u0111\u1ed9ng t\u1ebf b\u00e0o n\u1ed9i sinh \u0111\u1ebfn v\u1ecb tr\u00ed t\u1ed5n th\u01b0\u01a1ng.<\/em><\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

S\u1ef1 di tr\u00fa c\u1ee7a t\u1ebf b\u00e0o g\u1ed1c: T\u1ea1i v\u1ecb tr\u00ed t\u1ed5n th\u01b0\u01a1ng, c\u00e1c y\u1ebfu t\u1ed1 g\u00e2y vi\u00eam \u0111\u01b0\u1ee3c gi\u1ea3i ph\u00f3ng s\u1ebd k\u00edch ho\u1ea1t t\u1ebf b\u00e0o n\u1ed9i m\u00f4 m\u1ea1ch m\u00e1u, bi\u1ec3u hi\u1ec7n c\u00e1c ph\u00e2n t\u1eed b\u1ec1 m\u1eb7t cho s\u1ef1 b\u00e1m d\u00ednh v\u00e0 di c\u01b0 c\u1ee7a t\u1ebf b\u00e0o g\u1ed1c. \u0110\u1ed3ng th\u1eddi, t\u1ebf b\u00e0o g\u1ed1c \u0111\u01b0\u1ee3c huy \u0111\u1ed9ng, t\u01b0\u01a1ng t\u00e1c v\u1edbi t\u1ebf b\u00e0o n\u1ed9i m\u00f4 m\u1ea1ch m\u00e1u \u0111\u1ec3 \u0111i xuy\u00ean qua m\u1ea1ch m\u00e1u, \u0111\u1ebfn v\u1ecb tr\u00ed t\u1ed5n th\u01b0\u01a1ng \u0111\u1ec3 ch\u1eefa l\u00e0nh.<\/p>\n\n\n\n

C\u00e1ch gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4<\/strong><\/p>\n\n\n\n


Tr\u01b0\u1edbc h\u1ebft, l\u00e0m sao \u0111\u1ec3 t\u1ebf b\u00e0o g\u1ed1c \u0111\u1ebfn \u0111\u01b0\u1ee3c v\u1ecb tr\u00ed t\u1ed5n th\u01b0\u01a1ng? C\u00f3 hai con \u0111\u01b0\u1eddng ch\u00ednh \u0111\u1ec3 \u0111\u01b0a t\u1ebf b\u00e0o g\u1ed1c \u0111\u1ebfn v\u00f9ng t\u1ed5n th\u01b0\u01a1ng l\u00e0 gh\u00e9p c\u1ee5c b\u1ed9 v\u00e0 truy\u1ec1n t\u0129nh m\u1ea1ch.<\/p>\n\n\n\n

\u0110\u1ed1i v\u1edbi gh\u00e9p c\u1ee5c b\u1ed9, t\u1ebf b\u00e0o g\u1ed1c \u0111\u01b0\u1ee3c ti\u00eam tr\u1ef1c ti\u1ebfp v\u00e0o v\u00f9ng t\u1ed5n th\u01b0\u01a1ng. \u0110\u00e2y l\u00e0 c\u00e1ch ch\u1ee7 \u0111\u1ed9ng \u0111\u1ec3 ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c ch\u1eafc ch\u1eafn r\u1eb1ng t\u1ebf b\u00e0o g\u1ed1c \u0111\u01b0\u1ee3c \u0111\u01b0a \u0111\u00fang \u0111\u1ebfn v\u1ecb tr\u00ed m\u00e0 b\u00e1c s\u0129 mong mu\u1ed1n.
\u0110\u1ed1i v\u1edbi con \u0111\u01b0\u1eddng ti\u00eam truy\u1ec1n qua t\u0129nh m\u1ea1ch, vi\u1ec7c ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng \u0111i c\u1ee7a t\u1ebf b\u00e0o ph\u1ee9c t\u1ea1p h\u01a1n. Th\u1ef1c t\u1ebf, t\u1ea1i v\u1ecb tr\u00ed t\u1ed5n th\u01b0\u01a1ng, t\u1ebf b\u00e0o t\u1ed5n th\u01b0\u01a1ng v\u00e0 c\u00e1c t\u1ebf b\u00e0o xung quanh n\u00f3 \u0111\u00e3 ti\u1ebft ra c\u00e1c t\u00edn hi\u1ec7u. B\u1ea3n ch\u1ea5t c\u1ee7a c\u00e1c t\u00edn hi\u1ec7u n\u00e0y l\u00e0 c\u00e1c y\u1ebfu t\u1ed1 h\u00f2a tan trong m\u00e1u, n\u00f3 s\u1ebd theo d\u00f2ng m\u00e1u \u0111\u1ebfn kh\u1eafp n\u01a1i trong c\u01a1 th\u1ec3 v\u1edbi th\u00f4ng tin ph\u00e1t ra b\u00e1o hi\u1ec7u r\u1eb1ng c\u00f3 t\u1ed5n th\u01b0\u01a1ng x\u1ea3y ra t\u1ea1i m\u1ed9t v\u1ecb tr\u00ed c\u1ee5 th\u1ec3 trong c\u01a1 th\u1ec3. T\u00f9y v\u1ecb tr\u00ed t\u1ed5n th\u01b0\u01a1ng kh\u00e1c nhau m\u00e0 c\u00e1c t\u00edn hi\u1ec7u ph\u00e1t ra s\u1ebd c\u00f3 nh\u1eefng \u0111\u1eb7c tr\u01b0ng ri\u00eang v\u00e0 nh\u1edd \u0111\u00f3 c\u00e1c t\u1ebf b\u00e0o g\u1ed1c c\u00f3 th\u1ec3 nh\u1eadn di\u1ec7n v\u00e0 \u0111i \u0111\u1ebfn \u0111\u01b0\u1ee3c \u0111\u00fang v\u1ecb tr\u00ed. B\u00ean c\u1ea1nh kh\u1ea3 n\u0103ng t\u1ef1 c\u00f3 c\u1ee7a c\u01a1 th\u1ec3, b\u00e1c s\u0129 c\u1ea7n ph\u1ea3i can thi\u1ec7p tr\u01b0\u1edbc \u0111\u00f3 nh\u1eb1m \u0111\u01b0a t\u1ebf b\u00e0o \u0111\u1ebfn \u0111\u00fang v\u1ecb tr\u00ed. T\u1ebf b\u00e0o g\u1ed1c \u0111\u01b0\u1ee3c nh\u1eadn t\u00edn hi\u1ec7u s\u1ebd b\u1eaft \u0111\u1ea7u qu\u00e1 tr\u00ecnh ho\u1ea1t h\u00f3a, di chuy\u1ec3n \u0111\u1ec3 \u0111i \u0111\u1ebfn v\u1ecb tr\u00ed t\u1ed5n th\u01b0\u01a1ng, tham gia ch\u1eefa l\u00e0nh v\u1ebft th\u01b0\u01a1ng. Qu\u00e1 tr\u00ecnh n\u00e0y \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 c\u01b0 tr\u00fa.
Qu\u00e1 tr\u00ecnh di chuy\u1ec3n ph\u1ee9c t\u1ea1p c\u1ee7a t\u1ebf b\u00e0o g\u1ed1c \u0111\u01b0\u1ee3c \u0111i\u1ec1u ph\u1ed1i b\u1edfi m\u1ed9t l\u01b0\u1ee3ng l\u1edbn c\u00e1c cytokine, ph\u00e2n t\u1eed b\u00e1m d\u00ednh v\u00e0 c\u00e1c y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng c\u1ea7n thi\u1ebft cho vi\u1ec7c ki\u1ec3m so\u00e1t t\u1ed1t s\u1ef1 t\u00e1i sinh c\u00e1c m\u00f4 ch\u1ee9c n\u0103ng m\u1ed9t c\u00e1ch an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3. Cytokine l\u00e0 c\u00e1c protein hay glycoprotein kh\u00f4ng ph\u1ea3i kh\u00e1ng th\u1ec3 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t v\u00e0 ph\u00f3ng th\u00edch b\u1edfi c\u00e1c t\u1ebf b\u00e0o b\u1ea1ch c\u1ea7u vi\u00eam v\u00e0 m\u1ed9t s\u1ed1 t\u1ebf b\u00e0o kh\u00e1c kh\u00f4ng ph\u1ea3i b\u1ea1ch c\u1ea7u. C\u00e1c protein n\u00e0y ho\u1ea1t \u0111\u1ed9ng trong vai tr\u00f2 l\u00e0 c\u00e1c ch\u1ea5t trung gian \u0111i\u1ec1u h\u00f2a gi\u1eefa c\u00e1c t\u1ebf b\u00e0o trong c\u01a1 th\u1ec3. Cytokine gi\u00fap t\u1ebf b\u00e0o \u201cs\u1ed1ng s\u00f3t\u201d, tham gia v\u00e0o r\u1ea5t nhi\u1ec1u qu\u00e1 tr\u00ecnh sinh h\u1ecdc trong c\u01a1 th\u1ec3 nh\u01b0 t\u1ea1o ph\u00f4i, sinh s\u1ea3n, t\u1ea1o m\u00e1u, \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch, vi\u00eam.<\/p>\n\n\n\n


Kh\u1ea3 n\u0103ng s\u1eeda ch\u1eefa t\u1ed5n th\u01b0\u01a1ng<\/strong>
C\u00e1c t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 (Mesenchymal Stem Cell \u2013 MSC) l\u00e0 c\u00e1c t\u1ebf b\u00e0o g\u1ed1c \u0111a ti\u1ec1m n\u0103ng, c\u00f3 th\u1ec3 bi\u1ec7t h\u00f3a th\u00e0nh nhi\u1ec1u lo\u1ea1i t\u1ebf b\u00e0o kh\u00e1c nhau c\u1ee7a m\u00f4 bao g\u1ed3m nguy\u00ean b\u00e0o x\u01b0\u01a1ng, nguy\u00ean b\u00e0o s\u1ee5n, t\u1ebf b\u00e0o c\u01a1, t\u1ebf b\u00e0o m\u1ee1,\u2026 Khi \u0111\u1ebfn \u0111\u01b0\u1ee3c v\u1ecb tr\u00ed t\u1ed5n th\u01b0\u01a1ng th\u00ec c\u00e1c MSC s\u1ebd th\u1ef1c hi\u1ec7n ch\u1ee9c n\u0103ng s\u1eeda ch\u1eefa b\u1eb1ng c\u00e1c c\u00e1ch kh\u00e1c nhau nh\u01b0 ti\u1ebfp t\u1ee5c t\u0103ng sinh \u0111\u1ec3 cung c\u1ea5p ngu\u1ed3n t\u1ebf b\u00e0o g\u1ed1c cho s\u1eeda ch\u1eefa t\u1ed5n th\u01b0\u01a1ng, tham gia bi\u1ec7t h\u00f3a tr\u1ef1c ti\u1ebfp th\u00e0nh t\u1ebf b\u00e0o ch\u1ee9c n\u0103ng, ho\u1eb7c ti\u1ebft ra c\u00e1c y\u1ebfu t\u1ed1 gi\u00fap huy \u0111\u1ed9ng t\u1ebf b\u00e0o n\u1ed9i sinh \u0111\u1ebfn v\u1ecb tr\u00ed t\u1ed5n th\u01b0\u01a1ng nh\u01b0 \u0111\u00e3 \u0111\u1ec1 c\u1eadp \u1edf tr\u00ean.
<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Kh\u1ea3 n\u0103ng bi\u1ec7t h\u00f3a c\u1ee7a t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 th\u00e0nh c\u00e1c t\u1ebf b\u00e0o kh\u00e1c.
Sau khi MSC \u0111i t\u1edbi c\u00e1c v\u00f9ng m\u00f4 b\u1ecb t\u1ed5n th\u01b0\u01a1ng, ch\u00fang t\u01b0\u01a1ng t\u00e1c ch\u1eb7t ch\u1ebd v\u1edbi c\u00e1c k\u00edch th\u00edch t\u1ea1i ch\u1ed7, nh\u01b0 c\u00e1c cytokine vi\u00eam, c\u00e1c ph\u1ed1i t\u1eed (ligand) c\u1ee7a Toll-like receptor (TLRs) v\u00e0 s\u1ef1 gi\u1ea3m oxy. C\u00e1c y\u1ebfu t\u1ed1 n\u00e0y c\u00f3 th\u1ec3 k\u00edch th\u00edch MSC s\u1ea3n xu\u1ea5t m\u1ed9t s\u1ed1 l\u01b0\u1ee3ng l\u1edbn c\u00e1c y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng \u0111\u1ec3 th\u1ef1c hi\u1ec7n nhi\u1ec1u ch\u1ee9c n\u0103ng cho s\u1ef1 t\u00e1i sinh m\u00f4. Nhi\u1ec1u y\u1ebfu t\u1ed1 l\u00e0 ch\u1ea5t trung gian quan tr\u1ecdng trong s\u1ef1 h\u00ecnh th\u00e0nh m\u1ea1ch v\u00e0 ng\u0103n ng\u1eeba qu\u00e1 tr\u00ecnh ch\u1ebft theo ch\u01b0\u01a1ng tr\u00ecnh c\u1ee7a t\u1ebf b\u00e0o, v\u00ed d\u1ee5 y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng n\u1ed9i m\u00f4 m\u1ea1ch m\u00e1u VEGF, y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng gi\u1ed1ng insulin 1 (IGF-1), y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng nguy\u00ean b\u00e0o s\u1ee3i c\u01a1 b\u1ea3n (bFGF), y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng t\u1ebf b\u00e0o gan (HGF), IL-6 v\u00e0 CCL-2.
Ngo\u00e0i ra, c\u00e1c MSC c\u00f3 \u0111\u1eb7c t\u00ednh l\u1ea9n tr\u00e1nh mi\u1ec5n d\u1ecbch n\u00ean c\u00f3 ti\u1ec1m n\u0103ng \u1ee9ng d\u1ee5ng l\u00e2m s\u00e0ng l\u1edbn, \u0111\u1eb7c bi\u1ec7t \u0111\u1ed1i v\u1edbi b\u1ec7nh m\u1ea3nh gh\u00e9p ch\u1ed1ng v\u1eadt ch\u1ee7 (graft-versus-host disease – GVHD).
MSC \u0111\u01b0\u1ee3c ch\u1ee9ng minh c\u00f3 hi\u1ec7u qu\u1ea3 trong \u0111i\u1ec1u tr\u1ecb nhi\u1ec1u b\u1ec7nh mi\u1ec5n d\u1ecbch \u1edf ng\u01b0\u1eddi. C\u01a1 ch\u1ebf suy gi\u1ea3m mi\u1ec5n d\u1ecbch do vi\u00eam l\u00e0 c\u01a1 s\u1edf cho vi\u1ec7c thi\u1ebft k\u1ebf c\u00e1c m\u00f4 h\u00ecnh \u1ee9ng d\u1ee5ng l\u00e2m s\u00e0ng c\u1ee7a MSC. \u0110\u1ea7u ti\u00ean, l\u1ef1a ch\u1ecdn th\u1eddi \u0111i\u1ec3m t\u1ed1i \u01b0u cho vi\u1ec7c gh\u00e9p MSC d\u1ef1a tr\u00ean c\u1ea5p \u0111\u1ed9 v\u00e0 t\u1ef7 l\u1ec7 ti\u1ebft cytokine kh\u00e1c nhau trong su\u1ed1t ti\u1ebfn tr\u00ecnh ph\u00e1t tri\u1ec3n b\u1ec7nh \u1edf c\u01a1 th\u1ec3 ng\u01b0\u1eddi b\u1ec7nh. Th\u1ee9 hai, s\u1eed d\u1ee5ng cytokine \u0111\u1ec3 c\u1ea3m \u1ee9ng t\u1ebf b\u00e0o tr\u01b0\u1edbc khi gh\u00e9p ho\u1eb7c b\u1ed5 sung cytokine tr\u01b0\u1edbc khi gh\u00e9p c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c \u1ee9ng d\u1ee5ng \u0111\u1ec3 c\u1ea3i thi\u1ec7n hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb c\u1ee7a MSC. Th\u1ee9 ba, hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb c\u1ee7a MSC ph\u1ee5 thu\u1ed9c v\u00e0o b\u1ea3n ch\u1ea5t c\u1ee7a c\u00e1c b\u1ec7nh kh\u00e1c nhau do m\u00f4i tr\u01b0\u1eddng vi\u00eam kh\u00e1c nhau. Ngay c\u1ea3 \u0111\u1ed1i v\u1edbi m\u1ed9t b\u1ec7nh c\u1ee5 th\u1ec3, s\u1ef1 \u0111a d\u1ea1ng c\u1ee7a vi m\u00f4i tr\u01b0\u1eddng trong c\u00e1c m\u00f4 kh\u00e1c nhau c\u0169ng c\u00f3 th\u1ec3 t\u1ea1o ra t\u00e1c d\u1ee5ng ch\u1eefa b\u1ec7nh kh\u00e1c nhau c\u1ee7a MSC. H\u01a1n n\u1eefa c\u01a1 ch\u1ebf ch\u00ednh x\u00e1c c\u1ee7a MSC trong c\u01a1 th\u1ec3 c\u00f3 th\u1ec3 ph\u1ee9c t\u1ea1p h\u01a1n so v\u1edbi nh\u1eefng th\u00f4ng tin thu nh\u1eadn \u0111\u01b0\u1ee3c \u1edf m\u1ee9c in vitro. Do \u0111\u00f3, vi\u1ec7c x\u00e1c \u0111\u1ecbnh c\u01a1 ch\u1ebf ch\u00ednh x\u00e1c s\u1ebd gi\u00fap ph\u00e1t tri\u1ec3n c\u00e1c ph\u00e1c \u0111\u1ed3 t\u1ed1t h\u01a1n cho vi\u1ec7c \u1ee9ng d\u1ee5ng l\u00e2m s\u00e0ng s\u1eed d\u1ee5ng MSC.
Nhi\u1ec1u nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ee9ng minh, ti\u1ec1m n\u0103ng c\u1ee7a MSC gi\u1ea3m d\u1ea7n theo tu\u1ed5i ng\u01b0\u1eddi hi\u1ebfn t\u1ebf b\u00e0o v\u00e0 th\u1eddi gian nu\u00f4i c\u1ea5y, do \u0111\u00f3 Hi\u1ec7p h\u1ed9i Qu\u1ed1c t\u1ebf v\u1ec1 Li\u1ec7u ph\u00e1p T\u1ebf b\u00e0o khuy\u1ebfn c\u00e1o ch\u1ec9 n\u00ean s\u1eed d\u1ee5ng MSC m\u1edbi t\u00e1ch t\u1eeb nh\u1eefng b\u1ec7nh nh\u00e2n tr\u1ebb tu\u1ed5i, kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng t\u1ebf b\u00e0o t\u1eeb ng\u01b0\u1eddi cao tu\u1ed5i, t\u1ebf b\u00e0o \u0111\u00e3 qua nu\u00f4i c\u1ea5y ho\u1eb7c b\u1ea3o qu\u1ea3n l\u1ea1nh (t\u1ebf b\u00e0o \u0111\u00e3 qua nu\u00f4i c\u1ea5y ho\u1eb7c b\u1ea3o qu\u1ea3n l\u1ea1nh s\u1ebd t\u0103ng kh\u1ea3 n\u0103ng chuy\u1ec3n th\u00e0nh d\u1ea1ng \u00e1c t\u00ednh, c\u00f3 kh\u1ea3 n\u0103ng t\u1ea1o u cao). Nh\u00ecn chung, c\u00e1c th\u1eed nghi\u1ec7m tr\u00ean \u0111\u00e3 cho th\u1ea5y t\u00ednh an to\u00e0n cao c\u1ee7a MSC khi s\u1eed d\u1ee5ng, \u0111\u1ed3ng th\u1eddi b\u1ec7nh nh\u00e2n ph\u1ea7n n\u00e0o c\u1ea3i thi\u1ec7n \u0111\u01b0\u1ee3c t\u00ecnh tr\u1ea1ng b\u1ec7nh.<\/p>\n\n\n\n


\u1ee8ng d\u1ee5ng trong ch\u1eefa b\u1ec7nh<\/strong>
Tr\u00ean m\u00f4 h\u00ecnh th\u00ed nghi\u1ec7m \u0111\u1ed9ng v\u1eadt, MSC \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh c\u00f3 kh\u1ea3 n\u0103ng l\u00e0m gi\u1ea3m s\u1ef1 ti\u1ebfn tri\u1ec3n c\u1ee7a nhi\u1ec1u b\u1ec7nh m\u1ea1n t\u00ednh nh\u01b0 c\u00e1c b\u1ec7nh tho\u00e1i h\u00f3a th\u1ea7n kinh (b\u1ec7nh Alzheimer, Parkinson), c\u00e1c b\u1ec7nh t\u1ef1 mi\u1ec5n (vi\u00ean kh\u1edbp d\u1ea1ng th\u1ea5p, ti\u1ec3u \u0111\u01b0\u1eddng typ I), c\u00e1c b\u1ec7nh tim m\u1ea1ch (nh\u1ed3i m\u00e1u c\u01a1 tim)\u2026
\u1ede ng\u01b0\u1eddi, trong kho\u1ea3ng 20 n\u0103m tr\u1edf l\u1ea1i \u0111\u00e2y, s\u1ed1 l\u01b0\u1ee3ng c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u00e0 ch\u1eefa tr\u1ecb s\u1eed d\u1ee5ng MSC \u0111\u00e3 t\u0103ng v\u01b0\u1ee3t b\u1eadc. Nh\u1eefng b\u1ec7nh \u0111\u01b0\u1ee3c quan t\u00e2m nhi\u1ec1u nh\u1ea5t bao g\u1ed3m c\u00e1c b\u1ec7nh tim m\u1ea1ch, c\u00e1c b\u1ec7nh t\u1ef1 mi\u1ec5n, vi\u00eam x\u01b0\u01a1ng kh\u1edbp, gan, r\u1ed1i lo\u1ea1n h\u00f4 h\u1ea5p\u2026
\u1ede Vi\u1ec7t Nam, c\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 t\u1ebf b\u00e0o g\u1ed1c \u0111\u00e3 xu\u1ea5t hi\u1ec7n t\u1eeb kh\u00e1 l\u00e2u, nh\u01b0ng th\u1eddi gian \u0111\u1ea7u ch\u1ee7 y\u1ebfu t\u1eadp trung v\u00e0o t\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u. G\u1ea7n \u0111\u00e2y \u0111\u00e3 c\u00f3 nhi\u1ec1u nghi\u00ean c\u1ee9u s\u00e2u h\u01a1n v\u1ec1 MSC, m\u1ed9t s\u1ed1 nh\u00f3m nghi\u00ean c\u1ee9u \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c nh\u1eefng th\u00e0nh c\u00f4ng nh\u1ea5t \u0111\u1ecbnh nh\u01b0 Vi\u1ec7n T\u1ebf b\u00e0o g\u1ed1c, \u0110H KHTN TP. HCM, B\u1ec7nh vi\u1ec7n Nhi Trung \u01b0\u01a1ng,\u2026 C\u00e1c nh\u00f3m n\u00e0y \u0111\u00e3 ph\u00e2n l\u1eadp \u0111\u01b0\u1ee3c MSC t\u1eeb nhi\u1ec1u ngu\u1ed3n kh\u00e1c nhau (t\u1ee7y x\u01b0\u01a1ng, m\u00f4 m\u1ee1, m\u00e1u cu\u1ed1ng r\u1ed1n, t\u0129nh m\u1ea1ch d\u00e2y r\u1ed1n,\u2026) v\u1edbi \u0111\u1ed9 tinh khi\u1ebft cao, \u0111\u1ed3ng th\u1eddi bi\u1ec7t h\u00f3a \u0111\u01b0\u1ee3c MSC th\u00e0nh nhi\u1ec1u d\u1ea1ng t\u1ebf b\u00e0o kh\u00e1c nhau nh\u01b0 t\u1ebf b\u00e0o t\u1ea1o x\u01b0\u01a1ng, c\u01a1 tim, t\u1ebf b\u00e0o beta tuy\u1ebfn t\u1ee5y,\u2026 M\u1ed9t s\u1ed1 b\u1ec7nh nh\u01b0 b\u1ec7nh ph\u1ed5i t\u1eafc ngh\u1ebdn m\u1ea1n t\u00ednh – COPD, tho\u00e1i h\u00f3a kh\u1edbp g\u1ed1i, b\u1ec7nh Lupus ban \u0111\u1ecf h\u1ec7 th\u1ed1ng, \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 1 \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1eefa tr\u1ecb b\u1eb1ng li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o g\u1ed1c \u1edf m\u1ed9t s\u1ed1 b\u1ec7nh vi\u1ec7n v\u00e0 thu \u0111\u01b0\u1ee3c k\u1ebft qu\u1ea3 kh\u1ea3 quan.<\/p>\n\n\n\n

TS V\u0169 B\u00edch Ng\u1ecdc<\/strong><\/p>\n\n\n\n

Ngu\u1ed3n: http:\/\/khoahocphattrien.vn<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Khi \u0111\u1ebfn \u0111\u01b0\u1ee3c v\u1ecb tr\u00ed t\u1ed5n th\u01b0\u01a1ng th\u00ec t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 s\u1ebd th\u1ef1c hi\u1ec7n ch\u1ee9c n\u0103ng s\u1eeda ch\u1eefa b\u1eb1ng c\u00e1c c\u00e1ch kh\u00e1c nhau nh\u01b0 ti\u1ebfp t\u1ee5c t\u0103ng sinh \u0111\u1ec3 cung c\u1ea5p ngu\u1ed3n t\u1ebf b\u00e0o g\u1ed1c cho s\u1eeda ch\u1eefa t\u1ed5n th\u01b0\u01a1ng, tham gia bi\u1ec7t h\u00f3a tr\u1ef1c ti\u1ebfp th\u00e0nh t\u1ebf b\u00e0o ch\u1ee9c n\u0103ng, ho\u1eb7c ti\u1ebft […]<\/p>\n","protected":false},"author":293,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[161],"tags":[],"class_list":["post-3653","post","type-post","status-publish","format-standard","hentry","category-ban-tin"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts\/3653","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/users\/293"}],"replies":[{"embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/comments?post=3653"}],"version-history":[{"count":1,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts\/3653\/revisions"}],"predecessor-version":[{"id":4500,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts\/3653\/revisions\/4500"}],"wp:attachment":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/media?parent=3653"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/categories?post=3653"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/tags?post=3653"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}