{"id":3661,"date":"2020-03-18T16:43:29","date_gmt":"2020-03-18T09:43:29","guid":{"rendered":"http:\/\/new.vientebaogoc.edu.vn\/?post_type=blog_post&#038;p=1090"},"modified":"2024-11-24T07:58:42","modified_gmt":"2024-11-24T00:58:42","slug":"cong-nghe-moi-cua-sci-san-xuat-dich-tiet-tu-te-bao-goc-trung-mo-dat-tieu-chuan-cho-ung-dung-tren-nguoi","status":"publish","type":"post","link":"https:\/\/sci.edu.vn\/home\/blog\/2020\/03\/18\/cong-nghe-moi-cua-sci-san-xuat-dich-tiet-tu-te-bao-goc-trung-mo-dat-tieu-chuan-cho-ung-dung-tren-nguoi\/","title":{"rendered":"C\u00f4ng ngh\u1ec7 m\u1edbi c\u1ee7a SCI: S\u1ea3n xu\u1ea5t d\u1ecbch ti\u1ebft t\u1eeb t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 \u0111\u1ea1t ti\u00eau chu\u1ea9n cho \u1ee9ng d\u1ee5ng tr\u00ean ng\u01b0\u1eddi"},"content":{"rendered":"\n<p class=\"has-text-color has-background has-luminous-vivid-orange-color has-cyan-bluish-gray-background-color\"> Vi\u1ec7c thu c\u00e1c ch\u1ea5t ti\u1ebft t\u1eeb t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 \u0111\u1ec3 l\u00e0m thu\u1ed1c l\u00e0 m\u1ed9t b\u01b0\u1edbc quan tr\u1ecdng trong qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t thu\u1ed1c. Th\u1ebf nh\u01b0ng r\u00e0o c\u1ea3n l\u1edbn nh\u1ea5t v\u1ec1 k\u0129 thu\u1eadt hi\u1ec7n t\u1ea1i \u0111\u00f3 l\u00e0 c\u00e1c ch\u1ea5t ti\u1ebft b\u1ecb tr\u1ed9n l\u1eabn trong m\u00f4i tr\u01b0\u1eddng nu\u00f4i t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4; nh\u01b0ng m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y ch\u00fang kh\u00f4ng \u0111\u1ea1t c\u00e1c ti\u00eau chu\u1ea9n \u0111\u1ec3 s\u1eed d\u1ee5ng tr\u00ean ng\u01b0\u1eddi. L\u1ea7n \u0111\u1ea7u ti\u00ean t\u1ea1i Vi\u1ec7n T\u1ebf b\u00e0o g\u1ed1c, Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Khoa h\u1ecdc T\u1ef1 nhi\u00ean, \u0110HQG Tp.HCM nghi\u00ean c\u1ee9u v\u00e0 s\u1ea3n xu\u1ea5t th\u00e0nh c\u00f4ng m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y \u0111\u1ec3 thu nh\u1eadn ch\u1ea5t ti\u1ebft t\u1eeb t\u1ebf b\u00e0o g\u1ed1c; quan tr\u1ecdng h\u01a1n l\u00e0 m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t theo c\u00f4ng ngh\u1ec7 v\u00e0 ti\u00eau chu\u1ea9n \u0111\u00e1p \u1ee9ng c\u00e1c ti\u00eau chu\u1ea9n kh\u1eaft khe c\u1ee7a s\u1ea3n ph\u1ea9m c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng tr\u00ean ng\u01b0\u1eddi. <\/p>\n\n\n\n<p class=\"has-drop-cap\">T\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 l\u00e0 m\u1ed9t lo\u1ea1i t\u1ebf b\u00e0o g\u1ed1c c\u00f3 nhi\u1ec1u \u0111\u1eb7c t\u00ednh \u0111\u1eb7c bi\u1ec7t. Kho\u1ea3ng 10 n\u0103m tr\u1edf l\u1ea1i \u0111\u00e2y, t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng nhi\u1ec1u v\u00e0 tr\u1edf th\u00e0nh lo\u1ea1i t\u1ebf b\u00e0o g\u1ed1c \u1ee9ng d\u1ee5ng nhi\u1ec1u nh\u1ea5t trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y. C\u01a1 ch\u1ebf tr\u1ecb li\u1ec7u c\u1ee7a ch\u00fang kh\u00e1 \u0111a d\u1ea1ng; trong \u0111\u00f3 c\u01a1 ch\u1ebf ti\u1ebft c\u00e1c ch\u1ea5t \u0111\u1ec3 t\u00e1c \u0111\u1ed9ng l\u00ean t\u1ebf b\u00e0o v\u00e0 m\u00f4 kh\u00e1c l\u00e0 m\u1ed9t c\u01a1 ch\u1ebf \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong \u0111i\u1ec1u tr\u1ecb. Ng\u00e0y c\u00e0ng nhi\u1ec1u b\u00e1o c\u00e1o cho th\u1ea5y t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 s\u1ea3n xu\u1ea5t ra ngo\u00e0i t\u1ebf b\u00e0o nhi\u1ec1u ch\u1ea5t c\u00f3 ho\u1ea1t t\u00ednh k\u00edch th\u00edch t\u1ebf b\u00e0o g\u1ed1c t\u1ef1 th\u00e2n (n\u1ed9i sinh) c\u1ee7a b\u1ec7nh nh\u00e2n t\u0103ng sinh, t\u1ef1 l\u00e0m m\u1edbi; \u1ee9c ch\u1ebf qu\u00e1 tr\u00ecnh x\u01a1 ho\u00e1; \u1ee9c ch\u1ebf qu\u00e1 tr\u00ecnh ch\u1ebft apoptosis. Vi\u1ec7c thu c\u00e1c ch\u1ea5t ti\u1ebft t\u1eeb t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 \u0111\u1ec3 l\u00e0m thu\u1ed1c l\u00e0 m\u1ed9t b\u01b0\u1edbc quan tr\u1ecdng trong qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t thu\u1ed1c. Th\u1ebf nh\u01b0ng r\u00e0o c\u1ea3n l\u1edbn nh\u1ea5t v\u1ec1 k\u0129 thu\u1eadt hi\u1ec7n t\u1ea1i \u0111\u00f3 l\u00e0 c\u00e1c ch\u1ea5t ti\u1ebft b\u1ecb tr\u1ed9n l\u1eabn trong m\u00f4i tr\u01b0\u1eddng nu\u00f4i t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4; nh\u01b0ng m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y ch\u00fang kh\u00f4ng \u0111\u1ea1t c\u00e1c ti\u00eau chu\u1ea9n \u0111\u1ec3 s\u1eed d\u1ee5ng tr\u00ean ng\u01b0\u1eddi. L\u1ea7n \u0111\u1ea7u ti\u00ean t\u1ea1i <a href=\"http:\/\/www.vientebaogoc.edu.vn\">Vi\u1ec7n T\u1ebf b\u00e0o g\u1ed1c<\/a>, Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Khoa h\u1ecdc T\u1ef1 nhi\u00ean, \u0110HQG Tp.HCM nghi\u00ean c\u1ee9u v\u00e0 s\u1ea3n xu\u1ea5t th\u00e0nh c\u00f4ng m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y \u0111\u1ec3 thu nh\u1eadn ch\u1ea5t ti\u1ebft t\u1eeb t\u1ebf b\u00e0o g\u1ed1c; quan tr\u1ecdng h\u01a1n l\u00e0 m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t theo c\u00f4ng ngh\u1ec7 v\u00e0 ti\u00eau chu\u1ea9n \u0111\u00e1p \u1ee9ng c\u00e1c ti\u00eau chu\u1ea9n kh\u1eaft khe c\u1ee7a s\u1ea3n ph\u1ea9m c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng tr\u00ean ng\u01b0\u1eddi.<\/p>\n\n\n\n<p>Theo c\u00e1c b\u00e1o c\u00e1o g\u1ea7n \u0111\u00e2y; t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 sau khi c\u1ea5y gh\u00e9p v\u00e0o c\u01a1 th\u1ec3 c\u00f3 th\u1ec3 t\u1ea1o n\u00ean c\u00e1c t\u00e1c \u0111\u1ed9ng \u0111i\u1ec1u tr\u1ecb nh\u1edd v\u00e0o 3 c\u01a1 ch\u1ebf ch\u00ednh:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>(1) Ch\u00fang c\u00f3 th\u1ec3 di chuy\u1ec3n \u0111\u1ebfn v\u1ecb tr\u00ed m\u00f4 t\u1ed5n th\u01b0\u01a1ng, bi\u1ec7t ho\u00e1 v\u00e0 thay th\u1ebf c\u00e1c t\u1ebf b\u00e0o t\u1ed5n th\u01b0\u01a1ng<\/li><li>(2) Ch\u00fang c\u00f3 th\u1ec3 g\u00e2y n\u00ean \u0111\u00e1p \u1ee9ng \u0111i\u1ec1u bi\u1ebfn mi\u1ec5n d\u1ecbch tr\u00ean c\u01a1 th\u1ec3 nh\u1eadn m\u00e0 t\u1eeb \u0111\u00f3 \u0111i\u1ec1u ch\u1ec9nh \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch<\/li><li>(3) Ch\u00fang c\u00f3 th\u1ec3 ti\u1ebft ra c\u00e1c ch\u1ea5t g\u00e2y n\u00ean c\u00e1c t\u00e1c \u0111\u1ed9ng theo ki\u1ec3u endocrine hay paracrine. <\/li><\/ul>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/vientebaogoc.edu.vn\/wp-content\/uploads\/2019\/07\/MSCCult-MV-1-1024x708.png\" alt=\"\" class=\"wp-image-9623\"\/><figcaption><strong>Nh\u1eefng \u0111\u1eb7c \u0111i\u1ec3m n\u1ed5i b\u1eadt c\u1ee7a c\u00f4ng ngh\u1ec7 MSCCult MV. <\/strong><\/figcaption><\/figure>\n\n\n\n<p>Hi\u1ec7n t\u1ea1i, m\u1ed9t s\u1ed1 s\u1ea3n ph\u1ea9m t\u1eeb t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 \u0111\u00e3 s\u1eed d\u1ee5ng m\u1ed9t trong nh\u1eefng c\u01a1 ch\u1ebf n\u00e0y \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb; trong \u0111\u00f3 vi\u1ec7c s\u1eed d\u1ee5ng d\u1ecbch ti\u1ebft t\u1eeb t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 c\u00f3 nhi\u1ec1u ti\u1ec1m n\u0103ng b\u1edfi l\u1ebd n\u00f3 l\u00e0 ph\u01b0\u01a1ng ph\u00e1p kh\u00f4ng ch\u1ee9a t\u1ebf b\u00e0o n\u00ean d\u1ec5 d\u00e0ng s\u1ea3n xu\u1ea5t v\u00e0 s\u1eed d\u1ee5ng. <\/p>\n\n\n\n<p>V\u1edbi c\u00e1c c\u00f4ng ngh\u1ec7 hi\u1ec7n t\u1ea1i, c\u00e1c ch\u1ea5t ti\u1ebft t\u1eeb t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 s\u1ebd tr\u1ed9n l\u1eabn\ntrong m\u00f4i tr\u01b0\u1eddng nu\u00f4i t\u1ebf b\u00e0o; vi\u1ec7c s\u1eed d\u1ee5ng cocktail n\u00e0y c\u00f3 nhi\u1ec1u h\u1ea1n ch\u1ebf v\u00ec m\u00f4i\ntr\u01b0\u1eddng nu\u00f4i t\u1ebf b\u00e0o kh\u00f4ng \u0111\u1ea1t ti\u00eau chu\u1ea9n s\u1eed d\u1ee5ng tr\u00ean ng\u01b0\u1eddi.<\/p>\n\n\n\n<p>\u0110\u1ec3 gi\u1ea3i quy\u1ebft v\u1ea5n \u0111\u1ec1 tr\u00ean, Vi\u1ec7n T\u1ebf b\u00e0o g\u1ed1c \u0111\u00e3 nghi\u00ean c\u1ee9u ph\u00e1t tri\u1ec3n m\u00f4i tr\u01b0\u1eddng\nnu\u00f4i c\u1ea5y (t\u00ean th\u01b0\u01a1ng m\u1ea1i MSCCult MV) l\u00e0 m\u00f4i tr\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t theo c\u00e1c ti\u00eau chu\u1ea9n\nd\u01b0\u1ee3c ph\u1ea9m \u0111\u1ec3 s\u1eed d\u1ee5ng tr\u00ean ng\u01b0\u1eddi. <\/p>\n\n\n\n<p>MSCCult MV c\u00f3 nhi\u1ec1u \u01b0u \u0111i\u1ec3m v\u01b0\u1ee3t tr\u1ed9i \u0111\u1ec3 vi\u1ec7c thu d\u1ecbch ti\u1ebft nh\u01b0:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Kh\u00f4ng ch\u1ee9a th\u00e0nh ph\u1ea7n t\u1eeb \u0111\u1ed9ng v\u1eadt<\/li><li>K\u00edch th\u00edch t\u1ebf b\u00e0o ti\u1ebft ch\u1ea5t nhi\u1ec1u h\u01a1n ra m\u00f4i tr\u01b0\u1eddng<\/li><li>B\u1ea3o v\u1ec7 c\u00e1c ch\u1ea5t ti\u1ebft kh\u00f4ng b\u1ecb m\u1ea5t ho\u1ea1t t\u00ednh v\u00e0 ph\u00e2n hu\u1ef7 <\/li><li>D\u1ecbch nu\u00f4i ch\u1ee9a ch\u1ea5t ti\u1ebft \u0111\u1ea1t ti\u00eau chu\u1ea9n s\u1eed d\u1ee5ng tr\u00ean ng\u01b0\u1eddi\n(<em>v\u1edbi \u0111i\u1ec1u ki\u1ec7n t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 \u0111\u1ea1t ti\u00eau chu\u1ea9n<\/em> <em>v\u00e0 quy tr\u00ecnh s\u1ea3n xu\u1ea5t\n\u0111\u1ea1t chu\u1ea9n)<\/em><\/li><\/ul>\n\n\n\n<p>T\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 ti\u1ebft ra ngo\u00e0i t\u1ebf b\u00e0o nhi\u1ec1u ch\u1ea5t kh\u00e1c nhau c\u00f3 th\u1ec3 chia th\u00e0nh\n3 nh\u00f3m ch\u00ednh:<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>C\u00e1c ph\u00e2n t\u1eed protein t\u1ef1 do, c\u00e1c peptide, c\u00e1c ch\u1ea5t ph\u00e2n t\u1eed nh\u1ecf <\/li><li>C\u00e1c t\u00fai ti\u1ebft l\u1edbn (microvesicles) <\/li><li>C\u00e1c t\u00fai ti\u1ebft nh\u1ecf nanovesciles (exosome) <\/li><\/ol>\n\n\n\n<p>C\u00e1c ph\u00e2n t\u1eed protein t\u1ef1 do c\u00f3 th\u1ec3 l\u00e0 c\u00e1c y\u1ebfu t\u1ed1 t\u0103ng t\u01b0\u1edfng nh\u01b0 EGF, FGF\u2026 Trong khi \u0111\u00f3 c\u00e1c t\u00fai ti\u1ebft ch\u1ee9a nhi\u1ec1u th\u00e0nh ph\u1ea7n kh\u00e1c nhau k\u1ec3 c\u1ea3 c\u00e1c ph\u00e2n t\u1eed RNA. Nh\u1eefng th\u00e0nh ph\u1ea7n ti\u1ebft n\u00e0y th\u1ef1c hi\u1ec7n nhi\u1ec1u vai tr\u00f2 sinh h\u1ecdc quan tr\u1ecdng t\u1eeb k\u00edch th\u00edch h\u00ecnh th\u00e0nh m\u1ea1ch m\u00e1u m\u1edbi, \u0111i\u1ec1u bi\u1ebfn mi\u1ec5n d\u1ecbch\u2026 <\/p>\n\n\n\n<p><em><strong>Tin: P. KHCN &amp; SHTT, SCI <\/strong><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Vi\u1ec7c thu c\u00e1c ch\u1ea5t ti\u1ebft t\u1eeb t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 \u0111\u1ec3 l\u00e0m thu\u1ed1c l\u00e0 m\u1ed9t b\u01b0\u1edbc quan tr\u1ecdng trong qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t thu\u1ed1c. Th\u1ebf nh\u01b0ng r\u00e0o c\u1ea3n l\u1edbn nh\u1ea5t v\u1ec1 k\u0129 thu\u1eadt hi\u1ec7n t\u1ea1i \u0111\u00f3 l\u00e0 c\u00e1c ch\u1ea5t ti\u1ebft b\u1ecb tr\u1ed9n l\u1eabn trong m\u00f4i tr\u01b0\u1eddng nu\u00f4i t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4; nh\u01b0ng m\u00f4i [&hellip;]<\/p>\n","protected":false},"author":293,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[161],"tags":[],"class_list":["post-3661","post","type-post","status-publish","format-standard","hentry","category-ban-tin"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts\/3661","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/users\/293"}],"replies":[{"embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/comments?post=3661"}],"version-history":[{"count":1,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts\/3661\/revisions"}],"predecessor-version":[{"id":4492,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts\/3661\/revisions\/4492"}],"wp:attachment":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/media?parent=3661"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/categories?post=3661"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/tags?post=3661"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}