{"id":3673,"date":"2020-03-23T14:27:20","date_gmt":"2020-03-23T07:27:20","guid":{"rendered":"http:\/\/new.vientebaogoc.edu.vn\/?post_type=blog_post&p=1166"},"modified":"2024-11-24T07:58:41","modified_gmt":"2024-11-24T00:58:41","slug":"he-mo-kha-nang-khoi-phuc-tri-nho-cua-benh-nhan-alzheimer","status":"publish","type":"post","link":"https:\/\/sci.edu.vn\/home\/blog\/2020\/03\/23\/he-mo-kha-nang-khoi-phuc-tri-nho-cua-benh-nhan-alzheimer\/","title":{"rendered":"H\u00e9 m\u1edf kh\u1ea3 n\u0103ng kh\u00f4i ph\u1ee5c tr\u00ed nh\u1edb c\u1ee7a b\u1ec7nh nh\u00e2n Alzheimer"},"content":{"rendered":"\n

Nghi\u00ean c\u1ee9u c\u1ee7a \u0110H Buffalo (M\u1ef9) c\u00f4ng b\u1ed1 h\u1ed3i \u0111\u1ea7u n\u0103m nay tr\u00ean t\u1ea1p ch\u00ed Brain \u0111\u01b0a ra m\u1ed9t c\u00e1ch ti\u1ebfp c\u1eadn m\u1edbi \u0111\u1ed1i v\u1edbi b\u1ec7nh Alzheimer b\u1eb1ng vi\u1ec7c \u0111\u1ea3o ng\u01b0\u1ee3c qu\u00e1 tr\u00ecnh m\u1ea5t tr\u00ed nh\u1edb.<\/em><\/strong><\/p>\n\n\n\n

Nghi\u00ean c\u1ee9u ch\u1ec9 ra m\u1ed9t c\u00e1ch ph\u1ee5c h\u1ed3i ch\u1ee9c n\u0103ng nh\u1edb c\u1ee7a n\u00e3o nh\u1edd ti\u1ebfp c\u1eadn ngo\u1ea1i di truy\u1ec1n.
Nh\u00f3m nghi\u00ean c\u1ee9u cho r\u1eb1ng b\u1eb1ng c\u00e1ch t\u1eadp trung v\u00e0o nh\u1eefng t\u00e1c nh\u00e2n ngo\u1ea1i di truy\u1ec1n (Epigenetics, ch\u1ec9 nh\u1eefng thay \u0111\u1ed5i tr\u00ean gene kh\u00f4ng ph\u1ea3i do tr\u00ecnh t\u1ef1 s\u1eafp x\u1ebfp DNA), h\u1ecd c\u00f3 th\u1ec3 \u0111\u1ea3o ng\u01b0\u1ee3c s\u1ef1 suy gi\u1ea3m tr\u00ed nh\u1edb tr\u00ean \u0111\u1ed9ng v\u1eadt th\u00ed nghi\u1ec7m.
Nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m tr\u00ean c\u00e1c con chu\u1ed9t mang \u0111\u1ed9t bi\u1ebfn gene b\u1ec7nh Alzheimer gia \u0111\u00ecnh (ch\u1ec9 vi\u1ec7c trong gia \u0111\u00ecnh c\u00f3 h\u01a1n m\u1ed9t ng\u01b0\u1eddi m\u1eafc b\u1ec7nh) v\u00e0 tr\u00ean m\u00f4 n\u00e3o ch\u1ebft c\u1ee7a ng\u01b0\u1eddi m\u1eafc b\u1ec7nh Alzheimer.
T\u00e1c gi\u1ea3 ch\u00ednh c\u1ee7a b\u00e0i b\u00e1o l\u00e0 TS. Zhen Yan hi\u1ec7n \u0111ang l\u00e0m vi\u1ec7c t\u1ea1i Tr\u01b0\u1eddng Y h\u1ecdc v\u00e0 Khoa h\u1ecdc y sinh Jacobs thu\u1ed9c \u0110H Buffalo (M\u1ef9).
Alzheimer c\u00f3 m\u1ed1i li\u00ean quan \u0111\u1ebfn c\u00e1c b\u1ea5t th\u01b0\u1eddng ngo\u1ea1i di truy\u1ec1n<\/strong>
B\u1ec7nh Alzheimer l\u00e0 k\u1ebft qu\u1ea3 t\u1eeb c\u00e1c nh\u00e2n t\u1ed1 r\u1ee7i ro \u0111\u1ebfn t\u1eeb c\u1ea3 gene v\u00e0 m\u00f4i tr\u01b0\u1eddng. Ch\u00fang k\u1ebft h\u1ee3p l\u1ea1i t\u1ea1o n\u00ean c\u00e1c thay \u0111\u1ed5i ngo\u1ea1i di truy\u1ec1n, d\u1eabn \u0111\u1ebfn thay \u0111\u1ed5i bi\u1ec3u hi\u1ec7n gene. Tuy nhi\u00ean \u0111\u1ebfn nay \u00edt ai hi\u1ec3u \u0111\u01b0\u1ee3c qu\u00e1 tr\u00ecnh n\u00e0y x\u1ea3y ra nh\u01b0 th\u1ebf n\u00e0o.
TS. Yan cho bi\u1ebft nh\u1eefng thay \u0111\u1ed5i ngo\u1ea1i di truy\u1ec1n c\u1ee7a Alzheimer x\u1ea3y ra ch\u1ee7 y\u1ebfu \u1edf giai \u0111o\u1ea1n mu\u1ed9n, khi b\u1ec7nh nh\u00e2n \u0111\u00e3 kh\u00f4ng th\u1ec3 nh\u1edb \u0111\u01b0\u1ee3c nh\u1eefng th\u00f4ng tin m\u1edbi h\u1ecdc g\u1ea7n \u0111\u00f3 v\u00e0 c\u00f3 nh\u1eefng bi\u1ec3u hi\u1ec7n suy gi\u1ea3m nh\u1eadn th\u1ee9c m\u1ea1nh.
M\u1ed9t l\u00fd do ch\u00ednh d\u1eabn \u0111\u1ebfn s\u1ef1 suy gi\u1ea3m nh\u1eadn th\u1ee9c l\u00e0 do c\u01a1 th\u1ec3 m\u1ea5t \u0111i c\u00e1c th\u1ee5 th\u1ec3 glutamate \u2013 th\u1ee5 th\u1ec3 \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng cho vi\u1ec7c h\u1ecdc v\u00e0 h\u00ecnh th\u00e0nh tr\u00ed nh\u1edb ng\u1eafn h\u1ea1n.<\/p>\n\n\n\n

\"\"
Vi\u1ec7c suy gi\u1ea3m c\u00e1c th\u1ee5 th\u1ec3 glutamate s\u1ebd \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ho\u1ea1t \u0111\u1ed9ng tr\u00ed nh\u1edb c\u1ee7a n\u00e3o<\/figcaption><\/figure>\n\n\n\n

\u201cCh\u00fang t\u00f4i th\u1ea5y r\u1eb1ng v\u1edbi b\u1ec7nh Alzheimer, c\u00e1c c\u1ea5u tr\u00fac \u0111\u01a1n v\u1ecb con c\u1ee7a th\u1ee5 th\u1ec3 glutamate \u1edf v\u1ecf n\u00e3o tr\u01b0\u1edbc b\u1ecb s\u1ee5t gi\u1ea3m, d\u1eabn \u0111\u1ebfn vi\u1ec7c c\u00e1c t\u00edn hi\u1ec7u k\u00edch th\u00edch b\u1ecb gi\u00e1n \u0111o\u1ea1n, l\u00e0m suy gi\u1ea3m ho\u1ea1t \u0111\u1ed9ng c\u1ee7a tr\u00ed nh\u1edb\u201d, TS. Yan cho hay.
C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u ph\u00e1t hi\u1ec7n ra r\u1eb1ng vi\u1ec7c m\u1ea5t th\u1ee5 th\u1ec3 glutamate l\u00e0 k\u1ebft qu\u1ea3 c\u1ee7a qu\u00e1 tr\u00ecnh ngo\u1ea1i di truy\u1ec1n, hay c\u00f2n g\u1ecdi l\u00e0 qu\u00e1 tr\u00ecnh \u1ee9c ch\u1ebf s\u1eeda \u0111\u1ed5i protein histone. Nh\u00f3m nghi\u00ean c\u1ee9u cho bi\u1ebft qu\u00e1 tr\u00ecnh n\u00e0y gia t\u0103ng \u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2nAlzheimer v\u00e0 \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y tr\u00ean c\u1ea3 chu\u1ed9t th\u00ed nghi\u1ec7m v\u00e0 c\u1ea3 m\u00f4 n\u00e3o ch\u1ebft c\u1ee7a b\u1ec7nh nh\u00e2n Alzheimer
TS. Yan gi\u1ea3i th\u00edch r\u1eb1ng c\u00e1c b\u1ed9 \u0111i\u1ec1u bi\u1ebfn protein histone s\u1ebd l\u00e0m thay \u0111\u1ed5i c\u1ea5u tr\u00fac c\u1ee7a nhi\u1ec5m s\u1eafc ch\u1ea5t (chromatin, m\u1ed9t t\u1ed5 ch\u1ee9c b\u1eadc th\u1ea5p h\u01a1n DNA v\u00e0 nhi\u1ec5m s\u1eafc th\u1ec3). Nh\u1eefng nhi\u1ec5m s\u1eafc ch\u1ea5t s\u1ebd \u0111i\u1ec1u khi\u1ec3n c\u00e1ch th\u1ee9c v\u1eadt li\u1ec7u di truy\u1ec1n ti\u1ebfp c\u1eadn b\u1ed9 m\u00e1y phi\u00ean m\u00e3 t\u1ebf b\u00e0o.
\u201cS\u1ef1 \u0111i\u1ec1u ch\u1ec9nh protein histone b\u1ea5t th\u01b0\u1eddng c\u00f3 li\u00ean h\u1ec7 v\u1edbi b\u1ec7nh Alzheimer ch\u00ednh l\u00e0 th\u1ee9 k\u00ecm h\u00e3m bi\u1ec3u hi\u1ec7n gene, l\u00e0m gi\u1ea3m th\u1ee5 th\u1ec3 glutamate, d\u1eabn \u0111\u1ebfn vi\u1ec7c m\u1ea5t ch\u1ee9c n\u0103ng c\u1ee7a xi n\u00e1p (synapse) v\u00e0 gi\u1ea3m tr\u00ed nh\u1edb,\u201d TS. Yan n\u00f3i
H\u01b0\u1edbng \u0111\u1ebfn c\u00e1c lo\u1ea1i thu\u1ed1c ti\u1ec1m n\u0103ng<\/strong>
Hi\u1ec3u \u0111\u01b0\u1ee3c qu\u00e1 tr\u00ecnh tr\u00ean \u0111\u00e3 m\u1edf ra m\u1ed9t h\u01b0\u1edbng \u0111i ti\u1ec1m n\u0103ng cho vi\u1ec7c \u0111i\u1ec1u ch\u1ebf thu\u1ed1c, b\u1edfi qu\u00e1 tr\u00ecnh \u1ee9c ch\u1ebf s\u1eeda \u0111\u1ed5i protein histone c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t ho\u1eb7c x\u00fac t\u00e1c b\u1eb1ng c\u00e1c enzyme.
\u201cNghi\u00ean c\u1ee9u n\u00e0y kh\u00f4ng ch\u1ec9 cho th\u1ea5y m\u1ed1i t\u01b0\u01a1ng quan gi\u1eefa nh\u1eefng thay \u0111\u1ed5i ngo\u1ea1i di truy\u1ec1n v\u00e0 b\u1ec7nh Alzheimer, m\u00e0 c\u00f2n cho th\u1ea5y c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh c\u00e1c r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng nh\u1eadn th\u1ee9c b\u1eb1ng c\u00e1ch nh\u1eafm v\u00e0o nh\u1eefng enzyme ngo\u1ea1i di truy\u1ec1n \u0111\u1ec3 kh\u00f4i ph\u1ee5c th\u1ee5 th\u1ec3 glutamate,\u201d TS. Yan chia s\u1ebb.<\/p>\n\n\n\n

\"\"
TS. Zhen Yan, Tr\u01b0\u1eddng Y h\u1ecdc v\u00e0 Khoa h\u1ecdc y sinh Jacobs c\u1ee7a \u0110H Buffalo, M\u1ef9.
<\/figcaption><\/figure>\n\n\n\n

C\u00e1c con chu\u1ed9t th\u00ed nghi\u1ec7m m\u1eafc b\u1ec7nh Alzheimer \u0111\u01b0\u1ee3c ti\u00eam 3 l\u1ea7n c\u00e1c lo\u1ea1i h\u1ee3p ch\u1ea5t \u0111\u1ec3 k\u00ecm h\u00e3m enzyme ki\u1ec3m so\u00e1t qu\u00e1 tr\u00ecnh \u1ee9c ch\u1ebf s\u1eeda \u0111\u1ed5i protein histone.
\u201cKhi chu\u1ed9t th\u00ed nghi\u1ec7m \u0111\u01b0\u1ee3c ti\u00eam ch\u1ea5t k\u00ecm h\u00e3m enzyme n\u00e0y, ch\u00fang t\u00f4i th\u1ea5y ch\u1ee9c n\u0103ng nh\u1eadn th\u1ee9c c\u1ee7a ch\u00fang \u0111\u01b0\u1ee3c \u201cc\u1ee9u\u201d. C\u00e1c v\u1eadt th\u00ed nghi\u1ec7m \u0111\u01b0\u1ee3c ki\u1ec3m tra b\u1eb1ng c\u00e1c b\u00e0i test \u0111\u00e1nh gi\u00e1 v\u1ec1 ch\u1ee9c n\u0103ng nh\u1edb nh\u1eadn d\u1ea1ng, nh\u1edb kh\u00f4ng gian v\u00e0 nh\u1edb ng\u1eafn h\u1ea1n.”
“Ch\u00fang t\u00f4i kh\u00e1 ng\u1ea1c nhi\u00ean khi th\u1ea5y nh\u1eadn th\u1ee9c c\u1ee7a ch\u00fang \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n m\u1ea1nh m\u1ebd\u201d TS. Yan cho hay. \u201c\u0110\u1ed3ng th\u1eddi, ch\u00fang t\u00f4i c\u0169ng th\u1ea5y bi\u1ec3u hi\u1ec7n kh\u00f4i ph\u1ee5c c\u1ee7a c\u00e1c th\u1ee5 th\u1ec3 glutamate v\u00e0 ch\u1ee9c n\u0103ng \u1edf v\u1ecf n\u00e3o tr\u01b0\u1edbc.\u201d
C\u00e1c chuy\u1ec3n bi\u1ebfn t\u00edch c\u1ef1c \u0111\u00f3 k\u00e9o d\u00e0i \u0111\u01b0\u1ee3c m\u1ed9t tu\u1ea7n.
Nh\u1eefng nghi\u00ean c\u1ee9u t\u01b0\u01a1ng lai s\u1ebd t\u1eadp trung v\u00e0o vi\u1ec7c ph\u00e1t tri\u1ec3n nh\u1eefng h\u1ee3p ch\u1ea5t c\u00f3 kh\u1ea3 n\u0103ng th\u00e2m nh\u1eadp v\u00e0o n\u00e3o hi\u1ec7u qu\u1ea3 v\u00e0 l\u00e2u d\u00e0i h\u01a1n.
L\u1ee3i th\u1ebf ngo\u1ea1i di truy\u1ec1n<\/strong>
TS. Yan gi\u1ea3i th\u00edch r\u1eb1ng c\u00e1c r\u1ed1i lo\u1ea1n v\u1ec1 n\u00e3o, ch\u1eb3ng h\u1ea1n nh\u01b0 b\u1ec7nh Alzheimer, th\u01b0\u1eddng l\u00e0 c\u00e1c b\u1ec7nh \u0111a gene, trong \u0111\u00f3 r\u1ea5t nhi\u1ec1u gene li\u00ean quan \u0111\u1ebfn qu\u00e1 t\u00ecnh v\u00e0 m\u1ed7i gene l\u1ea1i c\u00f3 t\u00e1c \u0111\u1ed9ng khi\u00eam t\u1ed1n.
Vi\u1ec7c ti\u1ebfp c\u1eadn ngo\u1ea1i di truy\u1ec1n kh\u00e1 thu\u1eadn l\u1ee3i b\u1edfi c\u00e1c qu\u00e1 tr\u00ecnh ngo\u1ea1i di truy\u1ec1n ki\u1ec3m so\u00e1t kh\u00f4ng ch\u1ec9 m\u1ed9t m\u00e0 c\u00f2n nhi\u1ec1u gene.
\u201cVi\u1ec7c ti\u1ebfp c\u1eadn ngo\u1ea1i di truy\u1ec1n c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh m\u1ed9t m\u1ea1ng l\u01b0\u1edbi c\u00e1c gene, do \u0111\u00f3 s\u1ebd c\u00f9ng kh\u00f4i ph\u1ee5c \u0111\u01b0\u1ee3c c\u00e1c t\u1ebf b\u00e0o v\u1ec1 tr\u1ea1ng th\u00e1i b\u00ecnh th\u01b0\u1eddng v\u00e0 kh\u00f4i ph\u1ee5c \u0111\u01b0\u1ee3c ch\u1ee9c n\u0103ng ph\u1ee9c t\u1ea1p c\u1ee7a n\u00e3o,\u201d TS. Yan gi\u1ea3i th\u00edch.
“Ch\u00fang t\u00f4i \u0111\u00e3 cung c\u1ea5p b\u1eb1ng ch\u1ee9ng cho th\u1ea5y s\u1ef1 ki\u1ec3m so\u00e1t ngo\u1ea1i di truy\u1ec1n b\u1ea5t th\u01b0\u1eddng trong bi\u1ec3u hi\u1ec7n v\u00e0 ho\u1ea1t \u0111\u1ed9ng c\u1ee7a th\u1ee5 th\u1ec3 glutemate \u0111\u00e3 \u0111\u00f3ng g\u00f3p v\u00e0o vi\u1ec7c suy gi\u1ea3m nh\u1eadn th\u1ee9c c\u1ee7a b\u1ec7nh Alzheimer. N\u1ebfu nhi\u1ec1u gene r\u1ed1i lo\u1ea1n c\u1ee7a b\u00eanh Alzheimer \u0111\u01b0\u1ee3c b\u00ecnh th\u01b0\u1eddng h\u00f3a b\u1eb1ng c\u00e1ch ki\u1ec3m so\u00e1t c\u00e1c enzyme bi\u1ec3u sinh c\u1ee5 th\u1ec3 th\u00ec s\u1ebd c\u00f3 kh\u1ea3 n\u0103ng kh\u00f4i ph\u1ee5c ch\u1ee9c n\u0103ng nh\u1eadn th\u1ee9c v\u00e0 h\u00e0nh vi.\u201d
Nghi\u00ean c\u1ee9u n\u00e0y \u0111\u01b0\u1ee3c t\u00e0i tr\u1ee3 2 tri\u1ec7u USD (R01-AG056060) t\u1eeb Vi\u1ec7n L\u00e3o h\u00f3a, thu\u1ed9c Vi\u1ec7n y t\u1ebf qu\u1ed1c gia (M\u1ef9), chuy\u00ean t\u1eadp trung v\u00e0o c\u00e1c chi\u1ebfn l\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb m\u1edbi cho b\u1ec7nh Alzheimer.
Ngu\u1ed3n: <\/strong>\u0110H Buffalo<\/a>
Ng\u00f4 H\u00e0 (Theo \u0110H Buffalo, M\u1ef9)<\/strong><\/p>\n\n\n\n

http:\/\/khoahocphattrien.vn\/khoa-hoc\/he-mo-kha-nang-khoi-phuc-tri-nho-cua-benh-nhan-alzheimer\/20190504112551648p1c160.htm<\/a>
<\/p>\n","protected":false},"excerpt":{"rendered":"

Nghi\u00ean c\u1ee9u c\u1ee7a \u0110H Buffalo (M\u1ef9) c\u00f4ng b\u1ed1 h\u1ed3i \u0111\u1ea7u n\u0103m nay tr\u00ean t\u1ea1p ch\u00ed Brain \u0111\u01b0a ra m\u1ed9t c\u00e1ch ti\u1ebfp c\u1eadn m\u1edbi \u0111\u1ed1i v\u1edbi b\u1ec7nh Alzheimer b\u1eb1ng vi\u1ec7c \u0111\u1ea3o ng\u01b0\u1ee3c qu\u00e1 tr\u00ecnh m\u1ea5t tr\u00ed nh\u1edb. Nghi\u00ean c\u1ee9u ch\u1ec9 ra m\u1ed9t c\u00e1ch ph\u1ee5c h\u1ed3i ch\u1ee9c n\u0103ng nh\u1edb c\u1ee7a n\u00e3o nh\u1edd ti\u1ebfp c\u1eadn ngo\u1ea1i di truy\u1ec1n.Nh\u00f3m […]<\/p>\n","protected":false},"author":293,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[161],"tags":[],"class_list":["post-3673","post","type-post","status-publish","format-standard","hentry","category-ban-tin"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts\/3673","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/users\/293"}],"replies":[{"embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/comments?post=3673"}],"version-history":[{"count":1,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts\/3673\/revisions"}],"predecessor-version":[{"id":4482,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts\/3673\/revisions\/4482"}],"wp:attachment":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/media?parent=3673"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/categories?post=3673"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/tags?post=3673"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}