{"id":3678,"date":"2020-03-23T15:09:18","date_gmt":"2020-03-23T08:09:18","guid":{"rendered":"http:\/\/new.vientebaogoc.edu.vn\/?post_type=blog_post&#038;p=1171"},"modified":"2024-11-24T07:58:41","modified_gmt":"2024-11-24T00:58:41","slug":"te-bao-goc-trung-mo-tu-mo-mo-co-the-dieu-tri-hieu-qua-suy-gan-cap-tren-chuot","status":"publish","type":"post","link":"https:\/\/sci.edu.vn\/home\/blog\/2020\/03\/23\/te-bao-goc-trung-mo-tu-mo-mo-co-the-dieu-tri-hieu-qua-suy-gan-cap-tren-chuot\/","title":{"rendered":"T\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 t\u1eeb m\u00f4 m\u1ee1 c\u00f3 th\u1ec3 \u0111i\u1ec1u tr\u1ecb hi\u1ec7u qu\u1ea3 suy gan c\u1ea5p tr\u00ean chu\u1ed9t"},"content":{"rendered":"\n<p><strong><em><strong>M\u1ed9t bi\u1ebfn ch\u1ee9ng nghi\u00eam tr\u1ecdng c\u1ee7a suy gan m\u00e3n t\u00ednh l\u00e0 suy gan c\u1ea5p t\u00ednh, m\u1ed9t h\u1ed9i ch\u1ee9ng \u0111\u01b0\u1ee3c bi\u1ebft c\u00f3 \u0111\u1eb7c \u0111i\u1ec3m l\u00e0 m\u1ea5t b\u00f9 c\u01a1 tim v\u00e0 x\u01a1 gan, v\u00e0 s\u1ef1 s\u1ed1ng s\u00f3t th\u1ea5p, c\u1ea7n gh\u00e9p gan s\u1edbm. Do s\u1ed1 l\u01b0\u1ee3ng ng\u01b0\u1eddi hi\u1ebfn gan c\u00f2n h\u1ea1n ch\u1ebf n\u00ean c\u1ea7n m\u1ed9t c\u00e1ch ti\u1ebfp c\u1eadn m\u1edbi \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh n\u00e0y.<\/strong><\/em><\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/vientebaogoc.edu.vn\/wp-content\/uploads\/2019\/03\/Screen-Shot-2019-03-23-at-2.58.32-PM-768x1024.png\" alt=\"\" class=\"wp-image-8932\"\/><figcaption><strong><strong>C\u00e1c giai \u0111o\u1ea1n t\u1ed5n th\u01b0\u01a1ng gan.&nbsp;\ufeff<\/strong><\/strong><\/figcaption><\/figure>\n\n\n\n<p><br \/>\u0110\u00e3 c\u00f3 nh\u1eefng ti\u1ebfn b\u1ed9 \u0111\u00e1ng k\u1ec3 trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh gan b\u1eb1ng c\u00e1ch t\u1eadn d\u1ee5ng c\u01a1 ch\u1ebf mi\u1ec5n d\u1ecbch v\u00e0 t\u00e1i t\u1ea1o trong th\u1eddi gian g\u1ea7n \u0111\u00e2y.<br \/><br \/>M\u1ed9t s\u1ed1 m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt c\u1ee7a x\u01a1 gan c\u1ea5p v\u00e0 m\u00e3n t\u00ednh \u0111\u00e3 \u0111\u01b0\u1ee3c gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 (MSCs). K\u1ebft qu\u1ea3 cho th\u1ea5y c\u00f3 c\u1ea3i thi\u1ec7n ch\u1ee9c n\u0103ng gan \u1edf nh\u1eefng chu\u1ed9t n\u00e0y. &nbsp;Tuy nhi\u00ean, c\u00e1c m\u00f4 h\u00ecnh n\u00e0y kh\u00f4ng m\u00f4 ph\u1ecfng \u0111\u00fang \u0111\u01b0\u1ee3c b\u1ec7nh gan c\u1ea5p t\u00ednh tr\u00ean ng\u01b0\u1eddi v\u1edbi c\u1ed5 tr\u01b0\u1edbng v\u00e0 t\u1eed vong s\u1edbm. B\u00ean c\u1ea1nh m\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u cho th\u1ea5y r\u1eb1ng MSC c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n ch\u1ee9c n\u0103ng gan trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh nh\u00e2n b\u1ecb x\u01a1 gan m\u00e3n t\u00ednh, c\u00e1c nghi\u00ean c\u1ee9u kh\u00e1c cho th\u1ea5y kh\u00f4ng c\u00f3 l\u1ee3i khi s\u1eed d\u1ee5ng ph\u01b0\u01a1ng ph\u00e1p n\u00e0y. Kh\u00f4ng r\u00f5 MSCs c\u00f3 l\u00e0m gi\u1ea3m ho\u1eb7c g\u00f3p ph\u1ea7n t\u1ea1o th\u00e0nh s\u1ee3i x\u01a1 trong gan v\u00e0 li\u1ec7u qu\u00e1 tr\u00ecnh n\u00e0y c\u00f3 ph\u1ee5 thu\u1ed9c v\u00e0o l\u1ed9 tr\u00ecnh v\u00e0 khung th\u1eddi gian d\u00f9ng thu\u1ed1c hay kh\u00f4ng. Do \u0111\u00f3, c\u1ea7n nhi\u1ec1u nghi\u00ean c\u1ee9u h\u01a1n n\u1eefa tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb MSC nh\u01b0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ch\u00ednh cho suy gan.<br \/>&nbsp;Trong nghi\u00ean c\u1ee9u n\u00e0y, nh\u00f3m \u0111\u00e3 kh\u1ea3o s\u00e1t vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c MSCs c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb m\u1ee1 (AD-MSCs) trong m\u1ed9t m\u00f4 h\u00ecnh th\u1ef1c nghi\u1ec7m suy gan c\u1ea5p t\u00ednh, \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n b\u1edfi s\u1ef1 \u1ee9 m\u1eadt \u1edf chu\u1ed9t nh\u1eaft. Nh\u1eefng con chu\u1ed9t tr\u1ea3i qua t\u00ecnh tr\u1ea1ng \u1ee9 m\u1eadt \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng ti\u00eam t\u0129nh m\u1ea1ch AD-MSC ng\u01b0\u1eddi ho\u1eb7c chu\u1ed9t.<\/p>\n\n\n\n<p>C\u00e1c nh\u00f3m chu\u1ed9t \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng AD-MSC chu\u1ed9t c\u00f3 \u00edt c\u1ed5 tr\u01b0\u1edbng, gi\u1ea3m gan v\u00e0 l\u00e1ch to, teo tinh ho\u00e0n \u00edt h\u01a1n, v\u00e0 c\u1ea3i thi\u1ec7n c\u00e1c th\u00f4ng s\u1ed1 sinh h\u00f3a huy\u1ebft thanh. C\u0169ng c\u00f3 s\u1ef1 c\u1ea3i thi\u1ec7n v\u1ec1 s\u1ef1 thay \u0111\u1ed5i m\u00f4 h\u1ecdc gan, trong \u0111\u00f3 di\u1ec7n t\u00edch x\u01a1 h\u00f3a v\u00e0 s\u1ef1 t\u0103ng \u0111\u01b0\u1eddng m\u1eadt gi\u1ea3m \u0111\u00e1ng k\u1ec3 \u1edf nh\u00f3m \u0111i\u1ec1u tr\u1ecb b\u1eb1ng AD-MSC chu\u1ed9t.<\/p>\n\n\n\n<p>Nh\u1eefng d\u1eef li\u1ec7u n\u00e0y h\u1ed7 tr\u1ee3 vi\u1ec7c s\u1eed d\u1ee5ng AD-MSC t\u1ef1 th\u00e2n trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh \u1ee9 m\u1eadt \u1edf ng\u01b0\u1eddi, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u1edf tr\u1ebb s\u01a1 sinh, g\u00e2y \u1ee9c ch\u1ebf m\u1eadt.<\/p>\n\n\n\n<p class=\"has-text-align-right\"><strong><em>(Ph\u1ea1m V\u0169)<br \/><\/em><\/strong><\/p>\n\n\n\n<p><strong><em>Tham kh\u1ea3o:<\/em><\/strong><\/p>\n\n\n\n<p><a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332216327640\">http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332216327640<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>M\u1ed9t bi\u1ebfn ch\u1ee9ng nghi\u00eam tr\u1ecdng c\u1ee7a suy gan m\u00e3n t\u00ednh l\u00e0 suy gan c\u1ea5p t\u00ednh, m\u1ed9t h\u1ed9i ch\u1ee9ng \u0111\u01b0\u1ee3c bi\u1ebft c\u00f3 \u0111\u1eb7c \u0111i\u1ec3m l\u00e0 m\u1ea5t b\u00f9 c\u01a1 tim v\u00e0 x\u01a1 gan, v\u00e0 s\u1ef1 s\u1ed1ng s\u00f3t th\u1ea5p, c\u1ea7n gh\u00e9p gan s\u1edbm. Do s\u1ed1 l\u01b0\u1ee3ng ng\u01b0\u1eddi hi\u1ebfn gan c\u00f2n h\u1ea1n ch\u1ebf n\u00ean c\u1ea7n m\u1ed9t c\u00e1ch ti\u1ebfp c\u1eadn [&hellip;]<\/p>\n","protected":false},"author":293,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[161],"tags":[],"class_list":["post-3678","post","type-post","status-publish","format-standard","hentry","category-ban-tin"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts\/3678","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/users\/293"}],"replies":[{"embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/comments?post=3678"}],"version-history":[{"count":1,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts\/3678\/revisions"}],"predecessor-version":[{"id":4477,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts\/3678\/revisions\/4477"}],"wp:attachment":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/media?parent=3678"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/categories?post=3678"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/tags?post=3678"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}