{"id":3679,"date":"2020-03-23T15:26:26","date_gmt":"2020-03-23T08:26:26","guid":{"rendered":"http:\/\/new.vientebaogoc.edu.vn\/?post_type=blog_post&#038;p=1172"},"modified":"2024-11-24T07:58:41","modified_gmt":"2024-11-24T00:58:41","slug":"ghep-te-bao-goc-trung-mo-co-the-lam-giam-tan-suat-co-giat-o-benh-nhan-dong-kinh","status":"publish","type":"post","link":"https:\/\/sci.edu.vn\/home\/blog\/2020\/03\/23\/ghep-te-bao-goc-trung-mo-co-the-lam-giam-tan-suat-co-giat-o-benh-nhan-dong-kinh\/","title":{"rendered":"Gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m t\u1ea7n su\u1ea5t co gi\u1eadt \u1edf b\u1ec7nh nh\u00e2n \u0111\u1ed9ng kinh"},"content":{"rendered":"\n<p><strong><em><strong>\u0110\u1ed9ng kinh l\u00e0 m\u1ed9t nh\u00f3m c\u00e1c t\u00ecnh tr\u1ea1ng th\u1ea7n kinh, \u0111\u1eb7c tr\u01b0ng b\u1edfi c\u01a1n co gi\u1eadt do ho\u1ea1t \u0111\u1ed9ng th\u1ea7n kinh v\u1ecf n\u00e3o qu\u00e1 m\u1ee9c v\u00e0 b\u1ea5t th\u01b0\u1eddng v\u00e0 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn h\u00e0ng ch\u1ee5c tri\u1ec7u ng\u01b0\u1eddi tr\u00ean to\u00e0n th\u1ebf gi\u1edbi. S\u1ed1 l\u01b0\u1ee3ng thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh gia t\u0103ng v\u00e0 s\u1ef1 k\u1ebft h\u1ee3p c\u1ee7a ch\u00fang nh\u1eb1m m\u1ee5c \u0111\u00edch ng\u0103n ch\u1eb7n c\u00e1c k\u00eanh natri ho\u1eb7c canxi ho\u1eb7c c\u00e1c m\u1ee5c ti\u00eau kh\u00e1c \u0111\u1ec3 gi\u00fap ch\u1ea5m d\u1ee9t c\u01a1n \u0111\u1ed9ng kinh. V\u00ec hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb c\u1ee7a thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh (AEDs) \u0111\u01b0\u1ee3c gi\u1edbi h\u1ea1n trong kho\u1ea3ng 20% \u200b\u200b-40% b\u1ec7nh nh\u00e2n, c\u00e1c ph\u01b0\u01a1ng ph\u00e1p thay th\u1ebf nh\u01b0 li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c coi l\u00e0 m\u1ed9t c\u00e1ch ti\u1ebfp c\u1eadn c\u00f3 tri\u1ec3n v\u1ecdng. Li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o g\u1ed1c \u0111\u00e3 s\u1edbm ch\u1ee9ng minh hi\u1ec7u qu\u1ea3 \u1edf nhi\u1ec1u \u0111\u1ed9ng v\u1eadt v\u00e0 con ng\u01b0\u1eddi.<\/strong><\/em><\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/vientebaogoc.edu.vn\/wp-content\/uploads\/2019\/03\/Screen-Shot-2019-03-23-at-2.48.06-PM-1024x513.png\" alt=\"\" class=\"wp-image-8921\"\/><figcaption><strong><em><strong>C\u00e1c nguy\u00ean nh\u00e2n g\u00e2y b\u1ec7nh \u0111\u1ed9ng kinh \u1edf ng\u01b0\u1eddi (theo WHO).&nbsp;\ufeff<\/strong><\/em><\/strong><\/figcaption><\/figure>\n\n\n\n<p>C\u00e1c k\u1ebft qu\u1ea3 tr\u00ean m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt \u1ee7ng h\u1ed9 li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o g\u1ed1c cho \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng \u0111\u1ed9ng kinh: c\u00e1c lo\u1ea1i t\u1ebf b\u00e0o g\u1ed1c, bao g\u1ed3m t\u1ebf b\u00e0o g\u1ed1c th\u1ea7n kinh, t\u1ebf b\u00e0o g\u1ed1c ph\u00f4i thai, b\u00e0o thai  v\u00e0 c\u00e1c t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong&nbsp; m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt \u0111\u1ed9ng kinh v\u1edbi m\u1ed9t s\u1ed1 m\u1ee9c \u0111\u1ed9 th\u00e0nh c\u00f4ng. Ti\u1ec1m n\u0103ng \u0111i\u1ec1u tr\u1ecb c\u1ee7a c\u00e1c t\u1ebf b\u00e0o g\u1ed1c c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c t\u0103ng c\u01b0\u1eddng b\u1eb1ng c\u00e1c c\u00f4ng c\u1ee5 k\u1ef9 thu\u1eadt ti\u00ean ti\u1ebfn nh\u01b0 \u0111\u00f3ng g\u00f3i t\u1ebf b\u00e0o, \u0111i\u1ec1u ch\u1ec9nh ch\u1ebf \u0111\u1ed9 nu\u00f4i c\u1ea5y v\u00e0 bi\u1ebfn \u0111\u1ed5i di truy\u1ec1n.<\/p>\n\n\n\n<p><br \/>Ch\u1ee9c n\u0103ng ch\u00ednh c\u1ee7a t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 t\u1ee7y x\u01b0\u01a1ng (MSCs) l\u00e0 \u0111\u1ec3 h\u1ed7 tr\u1ee3 vi\u1ec7c t\u1ea1o m\u00e1u v\u00e0 t\u1ea1o t\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u, v\u00e0 cung c\u1ea5p c\u00e1c t\u1ebf b\u00e0o c\u00f3 ngu\u1ed3n g\u1ed1c trung t\u00ednh nh\u01b0 t\u1ebf b\u00e0o x\u01b0\u01a1ng, t\u1ebf b\u00e0o s\u1ee5n v\u00e0 t\u1ebf b\u00e0o m\u1ee1. Vi\u1ec7c chuy\u1ec3n bi\u1ec7t ho\u00e1 (transdifferentiation) l\u00e0m cho ch\u00fang c\u00f3 nhi\u1ec1u h\u1ee9a h\u1eb9n cho \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh th\u1ea7n kinh. \u0110\u1eb7c bi\u1ec7t, vi\u1ec7c c\u1ea5y gh\u00e9p MSC th\u01b0\u1eddng l\u00e0m gi\u1ea3m s\u1ed1 l\u1ea7n co gi\u1eadt v\u00e0 b\u1ea3o to\u00e0n neuron t\u1ed1t h\u01a1n.<\/p>\n\n\n\n<p>Trong nghi\u00ean c\u1ee9u n\u00e0y, nh\u00f3m nghi\u00ean c\u1ee9u \u0111\u1ec1 xu\u1ea5t m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb cho b\u1ec7nh nh\u00e2n \u0111\u1ed9ng kinh c\u00f3 tri\u1ec7u ch\u1ee9ng kh\u00e1ng thu\u1ed1c b\u1eb1ng c\u00e1ch truy\u1ec1n MSC v\u00e0o t\u0129nh m\u1ea1ch v\u00e0 trong m\u00e0ng c\u1ee9ng. Nghi\u00ean c\u1ee9u s\u1eed d\u1ee5ng c\u00e1c t\u1ebf b\u00e0o g\u1ed1c t\u1ef1 th\u00e2n thu t\u1eeb tu\u1ef7 x\u01b0\u01a1ng.<\/p>\n\n\n\n<p>M\u1ee5c ti\u00eau c\u1ee7a nghi\u00ean c\u1ee9u l\u00e0 \u0111\u00e1nh gi\u00e1 t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 ban \u0111\u1ea7u c\u1ee7a vi\u1ec7c k\u1ebft h\u1ee3p s\u1eed d\u1ee5ng truy\u1ec1n MSC t\u1ef1 th\u00e2n v\u00e0 AED th\u00f4ng th\u01b0\u1eddng trong c\u00e1c b\u1ec7nh nh\u00e2n b\u1ecb \u0111\u1ed9ng kinh.<br \/><\/p>\n\n\n\n<p>C\u00e1c b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c thu tu\u1ef7 x\u01b0\u01a1ng. Sau \u0111\u00f3, t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 t\u1eeb tu\u1ef7 x\u01b0\u01a1ng \u0111\u01b0\u1ee3c ph\u00e2n l\u1eadp, nu\u00f4i c\u1ea5y v\u00e0 t\u0103ng sinh. C\u00e1c t\u1ebf b\u00e0o sau khi ki\u1ec3m tra \u0111\u01b0\u1ee3c huy\u1ec1n ph\u00f9 trong n\u01b0\u1edbc mu\u1ed1i v\u1edbi 5% huy\u1ebft thanh t\u1ef1 th\u00e2n v\u00e0 truy\u1ec1n t\u0129nh m\u1ea1ch v\u00e0 b\u01a1m v\u00e0o m\u00e0ng c\u1ee9ng. Kho\u1ea3ng 70 tri\u1ec7u t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c \u0111\u01b0a v\u00e0o m\u1ed7i b\u1ec7nh nh\u00e2n.<\/p>\n\n\n\n<p><br \/>K\u1ebft qu\u1ea3 cho th\u1ea5y&nbsp; gh\u00e9p MSC \u0111\u01b0\u1ee3c dung n\u1ea1p t\u1ed1t v\u00e0 kh\u00f4ng g\u00e2y ra b\u1ea5t k\u1ef3 t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng n\u00e0o. T\u1ea7n su\u1ea5t co gi\u1eadt, l\u00ean c\u01a1n \u0111\u1ed9ng kinh \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh l\u00e0 k\u1ebft qu\u1ea3 ch\u00ednh v\u00e0 \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 sau 1 n\u0103m. 3 trong s\u1ed1 10 b\u1ec7nh nh\u00e2n trong nh\u00f3m \u0111i\u1ec1u tr\u1ecb MSC \u0111\u1ea1t \u0111\u01b0\u1ee3c s\u1ef1 thuy\u00ean gi\u1ea3m r\u00f5 r\u1ec7t (kh\u00f4ng c\u00f3 c\u01a1n co gi\u1eadt k\u00e9o d\u00e0i t\u1eeb 1 n\u0103m tr\u1edf l\u00ean), v\u00e0 5 b\u1ec7nh nh\u00e2n kh\u00e1c t\u1eeb kh\u00f4ng \u0111\u00e1p \u1ee9ng v\u1edbi AED \u0111\u00e3 tr\u1edf th\u00e0nh \u0111\u00e1p \u1ee9ng v\u1edbi AED, trong khi ch\u1ec9 c\u00f3 2 trong s\u1ed1 12 b\u1ec7nh nh\u00e2n \u0111\u00e1p \u1ee9ng trong nh\u00f3m \u0111\u1ed1i ch\u1ee9ng (kh\u00e1c bi\u1ec7t c\u00f3 \u00fd ngh\u0129a, P = 0,0135) .<br \/>Nh\u01b0 v\u1eady, li\u1ec7u ph\u00e1p MSC c\u00f3 \u0111\u1eb7c t\u00ednh \u0111i\u1ec1u h\u00f2a mi\u1ec5n d\u1ecbch duy nh\u1ea5t v\u00e0 l\u00e0 m\u1ed9t \u1ee9ng c\u1eed vi\u00ean an to\u00e0n v\u00e0 h\u1ee9a h\u1eb9n cho li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o \u1edf b\u1ec7nh nh\u00e2n \u0111\u1ed9ng kinh kh\u00e1ng AED.<\/p>\n\n\n\n<p class=\"has-text-align-right\"><strong><em>(Ph\u1ea1m V\u0169)<\/em><\/strong><\/p>\n\n\n\n<p><strong><em>Xem th\u00eam t\u1ea1i:<\/em><\/strong><\/p>\n\n\n\n<p><a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1896112617300238\">http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1896112617300238<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u0110\u1ed9ng kinh l\u00e0 m\u1ed9t nh\u00f3m c\u00e1c t\u00ecnh tr\u1ea1ng th\u1ea7n kinh, \u0111\u1eb7c tr\u01b0ng b\u1edfi c\u01a1n co gi\u1eadt do ho\u1ea1t \u0111\u1ed9ng th\u1ea7n kinh v\u1ecf n\u00e3o qu\u00e1 m\u1ee9c v\u00e0 b\u1ea5t th\u01b0\u1eddng v\u00e0 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn h\u00e0ng ch\u1ee5c tri\u1ec7u ng\u01b0\u1eddi tr\u00ean to\u00e0n th\u1ebf gi\u1edbi. S\u1ed1 l\u01b0\u1ee3ng thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh gia t\u0103ng v\u00e0 s\u1ef1 k\u1ebft h\u1ee3p c\u1ee7a ch\u00fang nh\u1eb1m [&hellip;]<\/p>\n","protected":false},"author":293,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[161],"tags":[],"class_list":["post-3679","post","type-post","status-publish","format-standard","hentry","category-ban-tin"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts\/3679","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/users\/293"}],"replies":[{"embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/comments?post=3679"}],"version-history":[{"count":1,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts\/3679\/revisions"}],"predecessor-version":[{"id":4476,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts\/3679\/revisions\/4476"}],"wp:attachment":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/media?parent=3679"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/categories?post=3679"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/tags?post=3679"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}