{"id":5155,"date":"2025-07-23T16:41:11","date_gmt":"2025-07-23T09:41:11","guid":{"rendered":"https:\/\/sci.edu.vn\/home\/?p=5155"},"modified":"2025-07-23T16:41:11","modified_gmt":"2025-07-23T09:41:11","slug":"gioi-thieu-nghien-cuu-moi-cua-vien-te-bao-goc-exosome-tu-te-bao-goc-mo-mo-cai-thien-tinh-trang-lao-hoa-da","status":"publish","type":"post","link":"https:\/\/sci.edu.vn\/home\/blog\/2025\/07\/23\/gioi-thieu-nghien-cuu-moi-cua-vien-te-bao-goc-exosome-tu-te-bao-goc-mo-mo-cai-thien-tinh-trang-lao-hoa-da\/","title":{"rendered":"Gi\u1edbi thi\u1ec7u nghi\u00ean c\u1ee9u m\u1edbi c\u1ee7a Vi\u1ec7n T\u1ebf b\u00e0o g\u1ed1c: Exosome t\u1eeb t\u1ebf b\u00e0o g\u1ed1c m\u00f4 m\u1ee1 c\u1ea3i thi\u1ec7n t\u00ecnh tr\u1ea1ng l\u00e3o h\u00f3a da"},"content":{"rendered":"\n

Nghi\u00ean c\u1ee9u m\u1edbi \u0111\u00e2y c\u1ee7a c\u00e1c nghi\u00ean c\u1ee9u vi\u00ean c\u1ee7a Vi\u1ec7n T\u1ebf b\u00e0o g\u1ed1c, Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Khoa h\u1ecdc t\u1ef1 nhi\u00ean, \u0110\u1ea1i h\u1ecdc Qu\u1ed1c gia Tp.HCM v\u00e0 c\u1ee7a Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Y d\u01b0\u1ee3c Tp.HCM cho th\u1ea5y exosome t\u1eeb t\u1ebf b\u00e0o g\u1ed1c m\u00f4 m\u1ee1 c\u00f3 t\u00e1c d\u1ee5ng c\u1ea3i thi\u1ec7n t\u00ecnh tr\u1ea1ng l\u00e3o h\u00f3a da. Nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c xu\u1ea5t b\u1ea3n tr\u00ean t\u1ea1p ch\u00ed <\/em><\/strong>Clinical, Cosmetic and Investigational Dermatology<\/em><\/mark><\/strong><\/a>. (<\/mark><\/em><\/strong>https:\/\/doi.org\/10.2147\/CCID.S523936<\/em><\/mark><\/strong><\/a>)<\/mark><\/em><\/strong><\/p>\n\n\n\n

L\u00e3o h\u00f3a da b\u1ecb chi ph\u1ed1i b\u1edfi s\u1ef1 t\u01b0\u01a1ng t\u00e1c ph\u1ee9c t\u1ea1p c\u1ee7a c\u00e1c y\u1ebfu t\u1ed1 n\u1ed9i sinh v\u00e0 ngo\u1ea1i sinh, l\u00e0m suy gi\u1ea3m c\u1ea5u tr\u00fac v\u00e0 ch\u1ee9c n\u0103ng c\u1ee7a da theo th\u1eddi gian. L\u00e3o h\u00f3a n\u1ed9i sinh (tu\u1ed5i sinh h\u1ecdc) \u0111\u01b0\u1ee3c th\u00fac \u0111\u1ea9y b\u1edfi qu\u00e1 tr\u00ecnh di truy\u1ec1n v\u00e0 chuy\u1ec3n h\u00f3a, trong khi l\u00e3o h\u00f3a ngo\u1ea1i sinh di\u1ec5n ra nhanh h\u01a1n do \u1ea3nh h\u01b0\u1edfng c\u1ee7a m\u00f4i tr\u01b0\u1eddng, bao g\u1ed3m b\u1ee9c x\u1ea1 tia c\u1ef1c t\u00edm (UV), \u00f4 nhi\u1ec5m, h\u00fat thu\u1ed1c v\u00e0 m\u1ea5t c\u00e2n b\u1eb1ng dinh d\u01b0\u1ee1ng. Trong s\u1ed1 \u0111\u00f3, vi\u1ec7c ti\u1ebfp x\u00fac k\u00e9o d\u00e0i v\u1edbi \u00e1nh s\u00e1ng UV\u2014\u0111\u1eb7c bi\u1ec7t l\u00e0 UVA (315\u2013400 nm) v\u00e0 UVB (290\u2013315 nm)\u2014\u0111\u01b0\u1ee3c c\u00f4ng nh\u1eadn r\u1ed9ng r\u00e3i l\u00e0 nguy\u00ean nh\u00e2n ch\u00ednh g\u00e2y l\u00e3o h\u00f3a da (photoaging). L\u00e3o h\u00f3a da do \u00e1nh s\u00e1ng \u0111\u1eb7c tr\u01b0ng b\u1edfi c\u00e1c n\u1ebfp nh\u0103n s\u00e2u, kh\u00f4 da, thay \u0111\u1ed5i c\u1ea5u tr\u00fac b\u1ec1 m\u1eb7t v\u00e0 r\u1ed1i lo\u1ea1n s\u1eafc t\u1ed1, d\u1eabn \u0111\u1ebfn nh\u1eefng quan ng\u1ea1i h\u00e0ng \u0111\u1ea7u c\u1ea3 v\u1ec1 m\u1eb7t th\u1ea9m m\u1ef9 l\u1eabn y khoa. C\u00e1c li\u1ec7u ph\u00e1p truy\u1ec1n th\u1ed1ng, bao g\u1ed3m retinoid b\u00f4i ngo\u00e0i da v\u00e0 nhi\u1ec1u th\u1ee7 thu\u1eadt th\u1ea9m m\u1ef9, \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng nh\u1eb1m gi\u1ea3i quy\u1ebft nh\u1eefng v\u1ea5n \u0111\u1ec1 n\u00e0y nh\u01b0ng th\u01b0\u1eddng g\u00e2y k\u00edch \u1ee9ng da, m\u1ea9n \u0111\u1ecf ho\u1eb7c bong tr\u00f3c. Do \u0111\u00f3, l\u0129nh v\u1ef1c da li\u1ec5u v\u1eabn ti\u1ebfp t\u1ee5c t\u00ecm ki\u1ebfm c\u00e1c ph\u01b0\u01a1ng ph\u00e1p m\u1edbi, an to\u00e0n h\u01a1n v\u00e0 hi\u1ec7u qu\u1ea3 h\u01a1n.<\/p>\n\n\n\n

M\u1ed9t h\u01b0\u1edbng ti\u1ebfp c\u1eadn \u0111\u1ea7y h\u1ee9a h\u1eb9n trong tr\u1ebb h\u00f3a da l\u00e0 \u1ee9ng d\u1ee5ng tr\u1ecb li\u1ec7u exosome c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb t\u1ebf b\u00e0o g\u1ed1c m\u1ee1 (ADSCs). Exosome l\u00e0 c\u00e1c t\u00fai ngo\u1ea1i b\u00e0o k\u00edch th\u01b0\u1edbc nano, tham gia truy\u1ec1n th\u00f4ng tin gi\u1eefa c\u00e1c t\u1ebf b\u00e0o th\u00f4ng qua v\u1eadn chuy\u1ec3n protein, lipid v\u00e0 axit nucleic. Kh\u00e1c v\u1edbi li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o, exosome l\u00e0 m\u1ed9t chi\u1ebfn l\u01b0\u1ee3c \u201ckh\u00f4ng s\u1eed d\u1ee5ng t\u1ebf b\u00e0o\u201d, c\u00f3 th\u1ec3 gi\u1ea3m b\u1edbt r\u00e0o c\u1ea3n s\u1eed d\u1ee5ng v\u00e0 c\u1ea3i thi\u1ec7n t\u00ednh an to\u00e0n. Exosome t\u1eeb t\u1ebf b\u00e0o g\u1ed1c m\u1ee1 (ADSC-Exo) \u0111\u1eb7c bi\u1ec7t \u0111\u01b0\u1ee3c quan t\u00e2m trong da li\u1ec5u, do \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn kh\u1ea3 n\u0103ng gi\u1ea3m ho\u1ea1t \u0111\u1ed9ng \u03b2-galactosidase li\u00ean quan l\u00e3o h\u00f3a (SA-\u03b2-gal), \u1ee9c ch\u1ebf bi\u1ec3u hi\u1ec7n c\u00e1c protein li\u00ean quan l\u00e3o h\u00f3a v\u00e0 th\u00fac \u0111\u1ea9y t\u1ed5ng h\u1ee3p th\u00e0nh ph\u1ea7n ch\u1ea5t n\u1ec1n ngo\u1ea1i b\u00e0o (ECM) quan tr\u1ecdng, ti\u00eau bi\u1ec3u l\u00e0 collagen. Th\u00f4ng qua c\u00e1c c\u01a1 ch\u1ebf n\u00e0y, ADSC-Exo c\u00f3 ti\u1ec1m n\u0103ng ph\u1ee5c h\u1ed3i t\u00ednh to\u00e0n v\u1eb9n c\u1ee7a da b\u1ecb suy y\u1ebfu b\u1edfi qu\u00e1 tr\u00ecnh l\u00e3o h\u00f3a v\u00e0 c\u00e1c t\u00e1c \u0111\u1ed9ng m\u00f4i tr\u01b0\u1eddng.<\/p>\n\n\n\n

Nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y cho th\u1ea5y \u0111i\u1ec1u ki\u1ec7n thi\u1ebfu oxy (n\u1ed3ng \u0111\u1ed9 O2 d\u01b0\u1edbi 5%) c\u00f3 th\u1ec3 l\u00e0m t\u0103ng \u0111\u00e1ng k\u1ec3 \u0111\u1eb7c t\u00ednh tr\u1ecb li\u1ec7u c\u1ee7a t\u1ebf b\u00e0o g\u1ed1c. Khi \u0111\u01b0\u1ee3c nu\u00f4i c\u1ea5y trong \u0111i\u1ec1u ki\u1ec7n thi\u1ebfu oxy, t\u1ebf b\u00e0o g\u1ed1c m\u1ee1 (ADSCs) th\u1ec3 hi\u1ec7n kh\u1ea3 n\u0103ng s\u1ed1ng s\u00f3t v\u00e0 t\u0103ng sinh t\u1ed1t h\u01a1n, \u0111\u1ed3ng th\u1eddi t\u1ea1o ra exosome (hypADSC-Exo) v\u1edbi th\u00e0nh ph\u1ea7n ph\u00e2n t\u1eed \u0111\u1eb7c bi\u1ec7t kh\u00e1c bi\u1ec7t so v\u1edbi khi nu\u00f4i \u1edf \u0111i\u1ec1u ki\u1ec7n b\u00ecnh th\u01b0\u1eddng. Nh\u1eefng exosome \u0111\u01b0\u1ee3c t\u1ea1o ra trong \u0111i\u1ec1u ki\u1ec7n thi\u1ebfu oxy c\u00f3 th\u1ec3 ch\u1ee9a c\u00e1c microRNA v\u00e0 protein b\u1ea3o v\u1ec7, gi\u00fap ch\u1ed1ng l\u1ea1i stress oxy h\u00f3a, k\u00edch th\u00edch t\u0103ng sinh m\u1ea1ch m\u00e1u v\u00e0 c\u00f3 th\u1ec3 th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh t\u00e1i t\u1ea1o da hi\u1ec7u qu\u1ea3 h\u01a1n so v\u1edbi exosome t\u1ea1o ra \u1edf \u0111i\u1ec1u ki\u1ec7n th\u01b0\u1eddng. M\u1eb7c d\u00f9 nh\u1eefng k\u1ebft qu\u1ea3 b\u01b0\u1edbc \u0111\u1ea7u r\u1ea5t kh\u1ea3 quan, v\u1eabn c\u00f2n thi\u1ebfu nh\u1eefng nghi\u00ean c\u1ee9u r\u00f5 r\u00e0ng v\u1ec1 vi\u1ec7c li\u1ec7u hypADSC-Exo c\u00f3 th\u1ec3 h\u1ed7 tr\u1ee3 gi\u1ea3m thi\u1ec3u c\u00e1c bi\u1ec3u hi\u1ec7n ph\u1ee9c t\u1ea1p c\u1ee7a l\u00e3o h\u00f3a da do UV m\u00e3n t\u00ednh hay kh\u00f4ng\u2014c\u1ea3 \u1edf c\u1ea5p \u0111\u1ed9 t\u1ebf b\u00e0o (th\u00f4ng qua gi\u1ea3m qu\u00e1 tr\u00ecnh l\u00e3o h\u00f3a \u1edf nguy\u00ean b\u00e0o s\u1ee3i da) l\u1eabn \u1edf c\u1ea5p \u0111\u1ed9 m\u00f4 (c\u1ea3i thi\u1ec7n \u0111\u1ed9 \u1ea9m, \u0111\u1ed9 \u0111\u00e0n h\u1ed3i v\u00e0 m\u1eadt \u0111\u1ed9 collagen \u1edf da b\u1ecb l\u00e3o h\u00f3a do \u00e1nh s\u00e1ng).<\/p>\n\n\n\n

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H\u00ecnh 1. S\u1ef1 thay \u0111\u1ed5i bi\u1ec3u hi\u1ec7n da trong c\u00e1c nh\u00f3m kh\u1ea3o s\u00e1t.<\/strong><\/figcaption><\/figure>\n\n\n\n

Trong b\u1ed1i c\u1ea3nh \u0111\u00f3, nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y c\u1ee7a t\u00e1c gi\u1ea3 Hu\u1ef3nh B\u1ea1ch C\u00fac c\u00f9ng c\u00e1c c\u1ed9ng s\u1ef1 t\u1ea1i Vi\u1ec7n T\u1ebf b\u00e0o g\u1ed1c, Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Khoa h\u1ecdc t\u1ef1 nhi\u00ean, \u0110HQG Tp.HCM \u0111\u00e3 kh\u1ea3o s\u00e1t t\u00e1c \u0111\u1ed9ng in vitro v\u00e0 in vivo c\u1ee7a exosome t\u1eeb t\u1ebf b\u00e0o ADSC nu\u00f4i c\u1ea5y hypoxia trong vi\u1ec7c ph\u1ee5c h\u1ed3i t\u1ed5n th\u01b0\u01a1ng da li\u00ean quan \u0111\u1ebfn l\u00e3o h\u00f3a do \u00e1nh s\u00e1ng. \u1ede ph\u1ea7n in vitro, nh\u00f3m t\u00e1c gi\u1ea3 ti\u1ebfn h\u00e0nh t\u00e1ch nguy\u00ean b\u00e0o s\u1ee3i da ng\u01b0\u1eddi (HDFs) t\u1eeb m\u1eabu da b\u1ee5ng v\u00e0 k\u00edch th\u00edch l\u00e3o h\u00f3a b\u1eb1ng b\u1ee9c x\u1ea1 UV v\u1edbi li\u1ec1u th\u1ea5p g\u00e2y t\u1ed5n th\u01b0\u01a1ng nh\u01b0ng kh\u00f4ng gi\u1ebft ch\u1ebft t\u1ebf b\u00e0o. Sau \u0111\u00f3, c\u00e1c nguy\u00ean b\u00e0o s\u1ee3i l\u00e3o h\u00f3a \u0111\u01b0\u1ee3c x\u1eed l\u00fd b\u1eb1ng hypADSC-Exo \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 thay \u0111\u1ed5i v\u1ec1 h\u00ecnh th\u00e1i, t\u1ed1c \u0111\u1ed9 t\u0103ng sinh, c\u0169ng nh\u01b0 bi\u1ec3u hi\u1ec7n gene li\u00ean quan l\u00e3o h\u00f3a. C\u1ee5 th\u1ec3, nh\u00f3m t\u00e1c gi\u1ea3 xem x\u00e9t s\u1ef1 \u0111i\u1ec1u ch\u1ec9nh c\u1ee7a c\u00e1c y\u1ebfu t\u1ed1 \u0111i\u1ec1u h\u00f2a l\u00e3o h\u00f3a p16 v\u00e0 p21, \u0111\u1ed3ng th\u1eddi \u0111o m\u1ee9c \u0111\u1ed9 ho\u1ea1t \u0111\u1ed9ng c\u1ee7a SA-\u03b2-galactosidase \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh kh\u1ea3 n\u0103ng exosome c\u00f3 th\u1ec3 \u201c\u0111\u1ea3o ng\u01b0\u1ee3c\u201d hi\u1ec7n t\u01b0\u1ee3ng l\u00e3o h\u00f3a \u1edf t\u1ebf b\u00e0o.<\/p>\n\n\n\n

\u1ede ph\u1ea7n in vivo, nh\u00f3m t\u00e1c gi\u1ea3 s\u1eed d\u1ee5ng m\u00f4 h\u00ecnh chu\u1ed9t b\u1ecb l\u00e3o h\u00f3a da do ti\u1ebfp x\u00fac UV m\u00e3n t\u00ednh, m\u00f4 ph\u1ecfng t\u00ecnh tr\u1ea1ng l\u00e3o h\u00f3a do \u00e1nh s\u00e1ng \u1edf ng\u01b0\u1eddi. Qu\u00e1 tr\u00ecnh b\u00f4i hypADSC-Exo t\u1ea1i ch\u1ed7 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n 2 l\u1ea7n m\u1ed7i tu\u1ea7n trong 6 tu\u1ea7n, k\u00e8m theo \u0111\u00e1nh gi\u00e1 \u0111\u1ecbnh k\u1ef3 v\u1ec1 h\u1ec7 s\u1ed1 nh\u0103n, \u0111\u1ed9 d\u00e0y da, \u0111\u1ed9 \u1ea9m, c\u00f9ng \u0111\u1ed9 \u0111\u00e0n h\u1ed3i\u2014c\u00e1c ch\u1ec9 s\u1ed1 ch\u00ednh c\u1ee7a t\u00ecnh tr\u1ea1ng da. K\u1ef9 thu\u1eadt nhu\u1ed9m m\u00f4 h\u1ecdc nh\u01b0 Hematoxylin & Eosin (H&E) v\u00e0 Masson\u2019s Trichrome \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 \u0111o \u0111\u1ecbnh l\u01b0\u1ee3ng \u0111\u1ed9 d\u00e0y c\u1ee7a l\u1edbp bi\u1ec3u b\u00ec, l\u1edbp b\u00ec v\u00e0 m\u1eadt \u0111\u1ed9 collagen. B\u00ean c\u1ea1nh \u0111\u00f3, nh\u00f3m t\u00e1c gi\u1ea3 c\u0169ng ph\u00e2n t\u00edch bi\u1ec3u hi\u1ec7n gene c\u1ee7a collagen lo\u1ea1i I v\u00e0 III, c\u0169ng nh\u01b0 c\u00e1c metalloproteinase (MMP) 1, 2 v\u00e0 3, \u0111\u1ec3 l\u00e0m r\u00f5 c\u00e1ch hypADSC-Exo \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn c\u00e1c con \u0111\u01b0\u1eddng ph\u00e2n t\u1eed d\u1eabn \u0111\u1ebfn l\u00e3o h\u00f3a da.<\/p>\n\n\n\n

K\u1ebft qu\u1ea3 c\u1ee7a nghi\u00ean c\u1ee9u cho th\u1ea5y hypADSC-Exo c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh t\u00edch c\u1ef1c l\u00e3o h\u00f3a da do \u00e1nh s\u00e1ng b\u1eb1ng nhi\u1ec1u c\u01a1 ch\u1ebf. K\u1ebft qu\u1ea3 in vitro cho th\u1ea5y, x\u1eed l\u00fd nguy\u00ean b\u00e0o s\u1ee3i HDFs b\u1ecb t\u1ed5n th\u01b0\u01a1ng b\u1edfi UV v\u1edbi hypADSC-Exo gi\u00fap gi\u1ea3m c\u00e1c d\u1ea5u hi\u1ec7u l\u00e3o h\u00f3a h\u00ecnh th\u00e1i v\u00e0 kh\u00f4i ph\u1ee5c k\u00edch th\u01b0\u1edbc t\u1ebf b\u00e0o tr\u1edf l\u1ea1i g\u1ea7n b\u00ecnh th\u01b0\u1eddng. T\u1ebf b\u00e0o \u0111\u01b0\u1ee3c x\u1eed l\u00fd duy tr\u00ec kh\u1ea3 n\u0103ng t\u0103ng sinh v\u00e0 gi\u1ea3m bi\u1ec3u hi\u1ec7n c\u00e1c marker l\u00e3o h\u00f3a p16, p21 theo th\u1eddi gian. Nh\u1eefng quan s\u00e1t n\u00e0y gi\u1ea3 \u0111\u1ecbnh r\u1eb1ng exosome t\u1eeb ADSC x\u1eed l\u00fd thi\u1ebfu oxy c\u00f3 th\u1ec3 ph\u00e1t huy hi\u1ec7u \u1ee9ng ch\u1ed1ng l\u00e3o h\u00f3a, kh\u1ea3 n\u0103ng cao nh\u1edd truy\u1ec1n t\u00edn hi\u1ec7u b\u1ea3o v\u1ec7 v\u00e0 ph\u1ee5c h\u1ed3i nh\u1eefng t\u1ed5n th\u01b0\u01a1ng do UV.<\/p>\n\n\n\n

T\u01b0\u01a1ng \u1ee9ng, \u1edf ph\u1ea7n in vivo, nh\u00f3m nghi\u00ean c\u1ee9u nh\u1eadn th\u1ea5y s\u1ef1 c\u1ea3i thi\u1ec7n v\u1ec1 di\u1ec7n m\u1ea1o v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng da sau khi b\u00f4i hypADSC-Exo li\u00ean t\u1ee5c. Nh\u1eefng con chu\u1ed9t \u0111\u01b0\u1ee3c b\u00f4i exosome \u1edf li\u1ec1u cao h\u01a1n c\u00f3 n\u1ebfp nh\u0103n \u00edt h\u01a1n, da \u1ea9m v\u00e0 \u0111\u00e0n h\u1ed3i t\u1ed1t h\u01a1n so v\u1edbi nh\u00f3m \u0111\u1ed1i ch\u1ee9ng ho\u1eb7c nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c. \u0110\u00e1ng ch\u00fa \u00fd, nh\u1eefng c\u1ea3i thi\u1ec7n n\u00e0y \u0111\u1ea1t \u0111\u01b0\u1ee3c v\u1edbi r\u1ea5t \u00edt d\u1ea5u hi\u1ec7u k\u00edch \u1ee9ng hay m\u1ea9n \u0111\u1ecf, m\u1ed9t l\u1ee3i th\u1ebf so v\u1edbi tretinoin b\u00f4i t\u1ea1i ch\u1ed7 (\u0111\u1ed1i ch\u1ee9ng d\u01b0\u01a1ng), v\u1ed1n \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn v\u1edbi t\u00ecnh tr\u1ea1ng bong tr\u00f3c, tr\u00f3c v\u1ea3y v\u00e0 ban \u0111\u1ecf. \u0110\u00e1nh gi\u00e1 m\u00f4 h\u1ecdc c\u1ee7ng c\u1ed1 th\u00eam k\u1ebft qu\u1ea3 n\u00e0y: l\u1edbp bi\u1ec3u b\u00ec chu\u1ed9t \u0111\u01b0\u1ee3c b\u00f4i hypADSC-Exo gi\u1ea3m hi\u1ec7n t\u01b0\u1ee3ng t\u0103ng s\u1ea3n, \u0111\u1ed3ng th\u1eddi m\u1eadt \u0111\u1ed9 collagen cao h\u01a1n. \u0110\u1ec3 gi\u1ea3i th\u00edch, nh\u00f3m t\u00e1c gi\u1ea3 cho r\u1eb1ng c\u1ea3i thi\u1ec7n n\u00e0y ch\u1ee7 y\u1ebfu \u0111\u1ebfn t\u1eeb vi\u1ec7c h\u1ea1 th\u1ea5p ho\u1ea1t \u0111\u1ed9ng c\u1ee7a MMP (v\u1ed1n l\u00e0m suy gi\u1ea3m collagen) v\u00e0 t\u0103ng c\u00f3 \u00fd ngh\u0129a bi\u1ec3u hi\u1ec7n gene collagen.<\/p>\n\n\n\n

V\u1ec1 ph\u00e2n t\u1eed, c\u00e1c metalloproteinase\u2014\u0111\u1eb7c bi\u1ec7t l\u00e0 MMP-1, MMP-2 v\u00e0 MMP-3\u2014\u0111\u00f3ng vai tr\u00f2 trung t\u00e2m trong qu\u00e1 tr\u00ecnh ph\u00e2n h\u1ee7y collagen \u1edf da l\u00e3o h\u00f3a do \u00e1nh s\u00e1ng. Vi\u1ec7c gi\u1ea3m thi\u1ec3u s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a c\u00e1c enzym n\u00e0y r\u1ea5t quan tr\u1ecdng \u0111\u1ec3 ph\u1ee5c h\u1ed3i ECM. B\u00ean c\u1ea1nh \u0111\u00f3, collagen lo\u1ea1i I v\u00e0 III l\u00e0 hai protein c\u1ea5u tr\u00fac ch\u1ee7 y\u1ebfu gi\u00fap duy tr\u00ec \u0111\u1ed9 s\u0103n ch\u1eafc v\u00e0 \u0111\u00e0n h\u1ed3i c\u1ee7a da. Vi\u1ec7c gia t\u0103ng ch\u00fang g\u00f3p ph\u1ea7n gi\u1ea3m n\u1ebfp nh\u0103n v\u00e0 l\u00e0m ph\u1eb3ng b\u1ec1 m\u1eb7t da th\u1ea5y r\u00f5. V\u00ec nguy\u00ean b\u00e0o s\u1ee3i l\u00e0 ngu\u1ed3n ch\u00ednh t\u1ea1o collagen \u1edf l\u1edbp b\u00ec, k\u00edch ho\u1ea1t l\u1ea1i qu\u1ea7n th\u1ec3 nguy\u00ean b\u00e0o s\u1ee3i c\u00f3 th\u1ec3 l\u00e0 c\u01a1 ch\u1ebf c\u1ed1t l\u00f5i gi\u00fap hypADSC-Exo th\u00fac \u0111\u1ea9y l\u00e0n da kh\u1ecfe m\u1ea1nh, tr\u1ebb trung h\u01a1n. M\u1eb7c d\u00f9 nghi\u00ean c\u1ee9u kh\u00f4ng ch\u1ec9 ra c\u1ee5 th\u1ec3 microRNA hay protein n\u00e0o trong exosome \u0111\u00f3ng vai tr\u00f2 ch\u00ednh, k\u1ebft qu\u1ea3 v\u1eabn ph\u00f9 h\u1ee3p v\u1edbi c\u00e1c t\u00e0i li\u1ec7u tr\u01b0\u1edbc \u0111\u00e2y v\u1ec1 vi\u1ec7c nu\u00f4i c\u1ea5y thi\u1ebfu oxy c\u00f3 kh\u1ea3 n\u0103ng bi\u1ebfn \u0111\u1ed5i th\u00e0nh ph\u1ea7n exosome l\u00e0m t\u0103ng c\u01a1 ch\u1ebf s\u1eeda ch\u1eefa.<\/p>\n\n\n\n

\u00dd ngh\u0129a c\u1ee7a nghi\u00ean c\u1ee9u n\u00e0y c\u00f3 hai \u0111i\u1ec3m ch\u00ednh. Th\u1ee9 nh\u1ea5t, n\u00f3 c\u1ee7ng c\u1ed1 ti\u1ec1m n\u0103ng c\u1ee7a exosome nh\u01b0 m\u1ed9t li\u1ec7u ph\u00e1p \u201ckh\u00f4ng t\u1ebf b\u00e0o\u201d thay th\u1ebf cho li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o g\u1ed1c truy\u1ec1n th\u1ed1ng, t\u1eeb \u0111\u00f3 m\u1edf ra h\u01b0\u1edbng ph\u00e1t tri\u1ec3n c\u00e1c s\u1ea3n ph\u1ea9m d\u01b0\u1ee3c m\u1ef9 ph\u1ea9m m\u1edbi d\u1ec5 ti\u00eau chu\u1ea9n h\u00f3a v\u00e0 s\u1eed d\u1ee5ng h\u01a1n. Th\u1ee9 hai, nghi\u00ean c\u1ee9u nh\u1ea5n m\u1ea1nh \u01b0u th\u1ebf c\u1ee7a exosome t\u1eeb t\u1ebf b\u00e0o g\u1ed1c m\u1ee1 \u0111\u01b0\u1ee3c nu\u00f4i trong \u0111i\u1ec1u ki\u1ec7n thi\u1ebfu oxy v\u01b0\u1ee3t tr\u1ed9i so v\u1edbi exosome nu\u00f4i c\u1ea5y trong \u0111i\u1ec1u ki\u1ec7n th\u01b0\u1eddng, t\u1eeb \u0111\u00f3 nh\u1ea5n m\u1ea1nh t\u1ea7m quan tr\u1ecdng c\u1ee7a vi\u1ec7c t\u1ed1i \u01b0u h\u00f3a \u0111i\u1ec1u ki\u1ec7n nu\u00f4i c\u1ea5y \u0111\u1ec3 gia t\u0103ng hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb. D\u00f9 nh\u00f3m t\u00e1c gi\u1ea3 nh\u1eadn \u0111\u1ecbnh c\u1ea7n th\u00eam nhi\u1ec1u kh\u1ea3o s\u00e1t h\u01a1n\u2014\u0111\u1eb7c bi\u1ec7t v\u1ec1 li\u1ec1u d\u00f9ng t\u1ed1i \u01b0u, m\u1ee9c \u0111\u1ed9 th\u1ea9m th\u1ea5u qua da ng\u01b0\u1eddi v\u00e0 t\u00e1c \u0111\u1ed9ng d\u00e0i h\u1ea1n\u2014nghi\u00ean c\u1ee9u n\u00e0y \u0111\u00e3 \u0111\u01b0a ra nh\u1eadn \u0111\u1ecbnh ti\u1ec1m n\u0103ng cho \u1ee9ng d\u1ee5ng l\u00e2m s\u00e0ng. C\u00e1c nghi\u00ean c\u1ee9u t\u01b0\u01a1ng lai c\u00f3 th\u1ec3 t\u1eadp trung v\u00e0o vi\u1ec7c tinh ch\u1ec9nh c\u00f4ng th\u1ee9c b\u00e0o ch\u1ebf t\u1ea1i ch\u1ed7 ph\u00f9 h\u1ee3p \u0111\u1ec3 t\u0103ng h\u1ea5p th\u1ee5 exosome, kh\u1ea3o s\u00e1t tr\u00ean m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt l\u1edbn h\u01a1n, c\u0169ng nh\u01b0 x\u00e1c \u0111\u1ecbnh th\u00e0nh ph\u1ea7n sinh h\u1ecdc ch\u1ee7 ch\u1ed1t trong exosome.<\/p>\n\n\n\n

T\u00f3m l\u1ea1i, nghi\u00ean c\u1ee9u n\u00e0y \u0111\u00e3 l\u00e0m phong ph\u00fa hi\u1ec3u bi\u1ebft c\u1ee7a ch\u00fang ta v\u1ec1 kh\u1ea3 n\u0103ng ch\u1ed1ng l\u1ea1i qu\u00e1 tr\u00ecnh l\u00e3o h\u00f3a da do \u00e1nh s\u00e1ng c\u1ee7a hypADSC-Exo. B\u1eb1ng c\u00e1ch t\u00e1c \u0111\u1ed9ng l\u00ean con \u0111\u01b0\u1eddng l\u00e3o h\u00f3a, t\u0103ng c\u01b0\u1eddng l\u1eafng \u0111\u1ecdng collagen, v\u00e0 gi\u1ea3m thi\u1ec3u s\u1ef1 ph\u00e2n h\u1ee7y ECM th\u00f4ng qua MMP, hypADSC-Exo cho th\u1ea5y ti\u1ec1m n\u0103ng nh\u01b0 m\u1ed9t li\u1ec7u ph\u00e1p thay th\u1ebf ho\u1eb7c b\u1ed5 tr\u1ee3 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 h\u01a1n so v\u1edbi c\u00e1c li\u1ec7u ph\u00e1p truy\u1ec1n th\u1ed1ng nh\u01b0 retinoid. Nh\u1eefng ph\u00e1t hi\u1ec7n n\u00e0y mang \u00fd ngh\u0129a r\u1ed9ng, t\u1eeb ph\u00e1t tri\u1ec3n s\u1ea3n ph\u1ea9m ch\u0103m s\u00f3c da \u0111\u1ebfn c\u00e1c can thi\u1ec7p l\u00e2m s\u00e0ng nh\u1eb1m kh\u00f4i ph\u1ee5c s\u1ee9c kh\u1ecfe l\u00e0n da. Khi da li\u1ec5u ng\u00e0y c\u00e0ng h\u01b0\u1edbng t\u1edbi nh\u1eefng li\u1ec7u ph\u00e1p t\u00e1i t\u1ea1o chuy\u00ean bi\u1ec7t, hypADSC-Exo n\u1ed5i l\u00ean nh\u01b0 m\u1ed9t ph\u01b0\u01a1ng th\u1ee9c kh\u00f4ng s\u1eed d\u1ee5ng t\u1ebf b\u00e0o, \u0111\u1ea7y t\u00ednh \u0111\u1ed9t ph\u00e1, c\u00f3 kh\u1ea3 n\u0103ng \u201cc\u00e1ch m\u1ea1ng h\u00f3a\u201d cu\u1ed9c chi\u1ebfn d\u00e0i h\u01a1i ch\u1ed1ng l\u1ea1i l\u00e3o h\u00f3a da do \u00e1nh s\u00e1ng.<\/p>\n","protected":false},"excerpt":{"rendered":"

Nghi\u00ean c\u1ee9u m\u1edbi \u0111\u00e2y c\u1ee7a c\u00e1c nghi\u00ean c\u1ee9u vi\u00ean c\u1ee7a Vi\u1ec7n T\u1ebf b\u00e0o g\u1ed1c, Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Khoa h\u1ecdc t\u1ef1 nhi\u00ean, \u0110\u1ea1i h\u1ecdc Qu\u1ed1c gia Tp.HCM v\u00e0 c\u1ee7a Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Y d\u01b0\u1ee3c Tp.HCM cho th\u1ea5y exosome t\u1eeb t\u1ebf b\u00e0o g\u1ed1c m\u00f4 m\u1ee1 c\u00f3 t\u00e1c d\u1ee5ng c\u1ea3i thi\u1ec7n t\u00ecnh tr\u1ea1ng l\u00e3o h\u00f3a da. Nghi\u00ean c\u1ee9u […]<\/p>\n","protected":false},"author":1,"featured_media":5156,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[161],"tags":[],"class_list":["post-5155","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ban-tin"],"jetpack_featured_media_url":"https:\/\/sci.edu.vn\/home\/wp-content\/uploads\/2025\/07\/2025-07-23-Hinh1.png","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts\/5155","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/comments?post=5155"}],"version-history":[{"count":1,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts\/5155\/revisions"}],"predecessor-version":[{"id":5157,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts\/5155\/revisions\/5157"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/media\/5156"}],"wp:attachment":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/media?parent=5155"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/categories?post=5155"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/tags?post=5155"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}