{"id":5433,"date":"2026-08-19T15:57:52","date_gmt":"2026-08-19T08:57:52","guid":{"rendered":"https:\/\/sci.edu.vn\/home\/?p=5433"},"modified":"2026-08-19T15:57:52","modified_gmt":"2026-08-19T08:57:52","slug":"cong-bo-nghien-cuu-ve-tac-dong-cua-paracetamol-va-metformin-len-tinh-nhay-cam-mien-dich-cua-te-bao-ung-thu-vu","status":"publish","type":"post","link":"https:\/\/sci.edu.vn\/home\/blog\/2026\/08\/19\/cong-bo-nghien-cuu-ve-tac-dong-cua-paracetamol-va-metformin-len-tinh-nhay-cam-mien-dich-cua-te-bao-ung-thu-vu\/","title":{"rendered":"C\u00f4ng b\u1ed1 nghi\u00ean c\u1ee9u v\u1ec1 t\u00e1c \u0111\u1ed9ng c\u1ee7a Paracetamol v\u00e0 Metformin l\u00ean t\u00ednh nh\u1ea1y c\u1ea3m mi\u1ec5n d\u1ecbch c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0 v\u00fa"},"content":{"rendered":"\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;6a85a4a12b097&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"6a85a4a12b097\" class=\"wp-block-image alignfull size-full wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"2560\" height=\"1707\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on--pointerdown=\"actions.preloadImage\" data-wp-on--pointerenter=\"actions.preloadImageWithDelay\" data-wp-on--pointerleave=\"actions.cancelPreload\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/sci.edu.vn\/home\/wp-content\/uploads\/2026\/08\/2026-08-19-scaled.png\" alt=\"\" class=\"wp-image-5435\" srcset=\"https:\/\/sci.edu.vn\/home\/wp-content\/uploads\/2026\/08\/2026-08-19-scaled.png 2560w, https:\/\/sci.edu.vn\/home\/wp-content\/uploads\/2026\/08\/2026-08-19-300x200.png 300w, https:\/\/sci.edu.vn\/home\/wp-content\/uploads\/2026\/08\/2026-08-19-1024x683.png 1024w, https:\/\/sci.edu.vn\/home\/wp-content\/uploads\/2026\/08\/2026-08-19-768x512.png 768w, https:\/\/sci.edu.vn\/home\/wp-content\/uploads\/2026\/08\/2026-08-19-1536x1024.png 1536w, https:\/\/sci.edu.vn\/home\/wp-content\/uploads\/2026\/08\/2026-08-19-2048x1365.png 2048w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\tdata-wp-bind--aria-label=\"state.thisImage.triggerButtonAriaLabel\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.thisImage.buttonRight\"\n\t\t\tdata-wp-style--top=\"state.thisImage.buttonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Nh\u00f3m nghi\u00ean c\u1ee9u t\u1ea1i Vi\u1ec7n T\u1ebf b\u00e0o g\u1ed1c, Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Khoa h\u1ecdc T\u1ef1 nhi\u00ean, \u0110HQG-HCM v\u1eeba c\u00f4ng b\u1ed1 c\u00f4ng tr\u00ecnh nghi\u00ean c\u1ee9u tr\u00ean t\u1ea1p ch\u00ed <a href=\"https:\/\/doi.org\/10.3390\/ijms27167211\" target=\"_blank\" rel=\"noreferrer noopener\"><em>International Journal of Molecular Sciences<\/em><\/a> (2026, 27(16), 7211) v\u1edbi t\u1ef1a \u0111\u1ec1: <em>&#8220;Paracetamol and Metformin Reduce NK-Cell Susceptibility in MCF-7 Breast Cancer Cells in Association with Enrichment of Immune-Evasive CD44+CD24\u2212 Stem-like Subpopulations&#8221;<\/em>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">C\u00f4ng tr\u00ecnh t\u1eadp trung l\u00e0m r\u00f5 t\u00e1c \u0111\u1ed9ng ngo\u00e0i \u00fd mu\u1ed1n c\u1ee7a hai lo\u1ea1i thu\u1ed1c th\u01b0\u1eddng d\u00f9ng trong \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 v\u00e0 qu\u1ea3n l\u00fd chuy\u1ec3n h\u00f3a \u1edf b\u1ec7nh nh\u00e2n ung th\u01b0: Paracetamol (APAP) v\u00e0 Metformin (MET).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Nh\u1eefng ph\u00e1t hi\u1ec7n n\u1ed5i b\u1eadt c\u1ee7a nghi\u00ean c\u1ee9u:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Ngh\u1ecbch l\u00fd \u0111i\u1ec1u tr\u1ecb:<\/strong> M\u1eb7c d\u00f9 \u1ee9c ch\u1ebf s\u1ef1 t\u0103ng sinh c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0 v\u00fa MCF-7 (<em>in vitro<\/em>), c\u1ea3 APAP v\u00e0 MET \u0111\u1ec1u th\u00fac \u0111\u1ea9y ki\u1ec3u h\u00ecnh l\u1ea9n tr\u00e1nh mi\u1ec5n d\u1ecbch, l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 ti\u00eau di\u1ec7t c\u1ee7a t\u1ebf b\u00e0o di\u1ec7t t\u1ef1 nhi\u00ean (NK cells).<\/li>\n\n\n\n<li><strong>L\u00e0m gi\u00e0u qu\u1ea7n th\u1ec3 t\u1ebf b\u00e0o g\u1ed1c ung th\u01b0 (CSC-like):<\/strong> C\u1ea3 hai ho\u1ea1t ch\u1ea5t \u0111\u1ec1u l\u00e0m t\u0103ng \u0111\u00e1ng k\u1ec3 t\u1ef7 l\u1ec7 ti\u1ec3u qu\u1ea7n th\u1ec3 t\u1ebf b\u00e0o mang \u0111\u1eb7c t\u00ednh t\u1ebf b\u00e0o g\u1ed1c <img loading=\"lazy\" decoding=\"async\" width=\"95\" height=\"27\" src=\"blob:https:\/\/sci.edu.vn\/413f2894-d6dd-4f79-8099-fa73d0168fd6\">\u2014v\u1ed1n c\u00f3 kh\u1ea3 n\u0103ng \u0111\u1ec1 kh\u00e1ng cao v\u1edbi s\u1ef1 t\u1ea5n c\u00f4ng c\u1ee7a t\u1ebf b\u00e0o NK.<\/li>\n\n\n\n<li><strong>T\u00e1i l\u1eadp tr\u00ecnh phi\u00ean m\u00e3:<\/strong> X\u1eed l\u00fd v\u1edbi APAP ho\u1eb7c MET d\u1eabn \u0111\u1ebfn s\u1ef1 gia t\u0103ng bi\u1ec3u hi\u1ec7n \u1edf m\u1ee9c phi\u00ean m\u00e3 c\u1ee7a c\u00e1c \u0111i\u1ec3m ki\u1ec3m so\u00e1t mi\u1ec5n d\u1ecbch (<em>PD-L1<\/em>, <em>PD-L2<\/em>), ph\u1ed1i t\u1eed stress (<em>MICA\/B<\/em>) v\u00e0 c\u00e1c ph\u00e2n t\u1eed \u0111\u1ed3ng k\u00edch th\u00edch (<em>CD80\/86<\/em>).<\/li>\n\n\n\n<li><strong>C\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng:<\/strong> APAP tr\u1ef1c ti\u1ebfp \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn t\u1ef7 l\u1ec7 s\u1ed1ng v\u00e0 ki\u1ec3u h\u00ecnh c\u1ee7a t\u1ebf b\u00e0o NK \u1edf n\u1ed3ng \u0111\u1ed9 cao, trong khi MET ch\u1ee7 y\u1ebfu t\u00e1c \u0111\u1ed9ng th\u00f4ng qua c\u00e1c bi\u1ebfn \u0111\u1ed5i n\u1ed9i t\u1ea1i c\u1ee7a t\u1ebf b\u00e0o kh\u1ed1i u.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">K\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u cung c\u1ea5p th\u00eam g\u00f3c nh\u00ecn c\u01a1 ch\u1ebf v\u1ec1 t\u01b0\u01a1ng t\u00e1c gi\u1eefa thu\u1ed1c \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 v\u00e0 h\u1ec7 mi\u1ec5n d\u1ecbch, nh\u1ea5n m\u1ea1nh s\u1ef1 c\u1ea7n thi\u1ebft ph\u1ea3i \u0111\u00e1nh gi\u00e1 to\u00e0n di\u1ec7n c\u00e1c li\u1ec7u ph\u00e1p k\u1ebft h\u1ee3p nh\u1eb1m t\u1ed1i \u01b0u h\u00f3a hi\u1ec7u qu\u1ea3 c\u1ee7a li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch trong t\u01b0\u01a1ng lai.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Chi ti\u1ebft b\u00e0i b\u00e1o \u0111\u01b0\u1ee3c \u0111\u0103ng t\u1ea3i t\u1ea1i: <a href=\"https:\/\/doi.org\/10.3390\/ijms27167211\" target=\"_blank\" rel=\"noreferrer noopener\">IJMS 2026, 27(16), 7211<\/a>.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading alignwide\">Study Published on the Effects of Paracetamol and Metformin on the Immune Susceptibility of Breast Cancer Cells<\/h2>\n\n\n\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;6a85a4a12bedd&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"6a85a4a12bedd\" class=\"wp-block-image alignfull size-full wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"1536\" height=\"1024\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on--pointerdown=\"actions.preloadImage\" data-wp-on--pointerenter=\"actions.preloadImageWithDelay\" data-wp-on--pointerleave=\"actions.cancelPreload\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/sci.edu.vn\/home\/wp-content\/uploads\/2026\/08\/10.3390_ijms27167211.webp\" alt=\"\" class=\"wp-image-5434\" srcset=\"https:\/\/sci.edu.vn\/home\/wp-content\/uploads\/2026\/08\/10.3390_ijms27167211.webp 1536w, https:\/\/sci.edu.vn\/home\/wp-content\/uploads\/2026\/08\/10.3390_ijms27167211-300x200.webp 300w, https:\/\/sci.edu.vn\/home\/wp-content\/uploads\/2026\/08\/10.3390_ijms27167211-1024x683.webp 1024w, https:\/\/sci.edu.vn\/home\/wp-content\/uploads\/2026\/08\/10.3390_ijms27167211-768x512.webp 768w\" sizes=\"auto, (max-width: 1536px) 100vw, 1536px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\tdata-wp-bind--aria-label=\"state.thisImage.triggerButtonAriaLabel\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.thisImage.buttonRight\"\n\t\t\tdata-wp-style--top=\"state.thisImage.buttonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">A research team at the Stem Cell Institute, University of Science, VNU-HCM has recently published an article in the International Journal of Molecular Sciences (2026, 27(16), 7211) titled: &#8220;Paracetamol and Metformin Reduce NK-Cell Susceptibility in MCF-7 Breast Cancer Cells in Association with Enrichment of Immune-Evasive CD44+CD24\u2212 Stem-like Subpopulations&#8221;.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study focuses on clarifying the unintended effects of two drugs widely used in supportive care and metabolic management for cancer patients: Paracetamol (APAP) and Metformin (MET).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Key Findings:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Therapeutic Paradox: Despite inhibiting the proliferation of MCF-7 breast cancer cells in vitro, both APAP and MET promote an immune-evasive phenotype, diminishing the cytotoxic efficacy of natural killer (NK) cells.<\/li>\n\n\n\n<li>Cancer Stem Cell-like (CSC-like) Enrichment: Both compounds significantly increase the proportion of the CD44+CD24\u2212 stem-like subpopulation, which is highly resistant to NK cell attack.<\/li>\n\n\n\n<li>Transcriptional Reprogramming: Treatment with APAP or MET upregulates the transcript-level expression of immune checkpoints (PD-L1, PD-L2), stress ligands (MICA\/B), and costimulatory molecules (CD80\/86). Mechanisms of Action: APAP directly affects NK cell viability and phenotype at high concentrations, whereas MET primarily exerts its effects through intrinsic tumor cell alterations.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">The study provides mechanistic insights into the interactions between supportive medications and antitumor immunity, underscoring the need for a comprehensive evaluation of combination therapies to optimize the efficacy of future immunotherapeutic strategies.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Article Details: IJMS 2026, 27(16), 7211.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nh\u00f3m nghi\u00ean c\u1ee9u t\u1ea1i Vi\u1ec7n T\u1ebf b\u00e0o g\u1ed1c, Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Khoa h\u1ecdc T\u1ef1 nhi\u00ean, \u0110HQG-HCM v\u1eeba c\u00f4ng b\u1ed1 c\u00f4ng tr\u00ecnh nghi\u00ean c\u1ee9u tr\u00ean t\u1ea1p ch\u00ed International Journal of Molecular Sciences (2026, 27(16), 7211) v\u1edbi t\u1ef1a \u0111\u1ec1: &#8220;Paracetamol and Metformin Reduce NK-Cell Susceptibility in MCF-7 Breast Cancer Cells in Association with Enrichment of Immune-Evasive CD44+CD24\u2212 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":5435,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[161],"tags":[],"class_list":["post-5433","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ban-tin"],"jetpack_featured_media_url":"https:\/\/sci.edu.vn\/home\/wp-content\/uploads\/2026\/08\/2026-08-19-scaled.png","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts\/5433","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/comments?post=5433"}],"version-history":[{"count":1,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts\/5433\/revisions"}],"predecessor-version":[{"id":5436,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/posts\/5433\/revisions\/5436"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/media\/5435"}],"wp:attachment":[{"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/media?parent=5433"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/categories?post=5433"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sci.edu.vn\/home\/wp-json\/wp\/v2\/tags?post=5433"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}